Impacts of daily intakes on the isomeric profiles of perfluoroalkyl substances (PFASs) in human serum.
Impacts of daily intakes on the isomeric profiles of perfluoroalkyl substances (PFASs) in human serum.
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DOI：
10.1016/j.envint.2016.01.002
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发表时间：
2016-04
影响因子：
11.8
通讯作者：
Guoqiang Shan;Zhi Wang;Lianqiu Zhou;Pin Du;Xiaoxiao Luo;Qiannian Wu;Lingyan Zhu
中科院分区：
文献类型：
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作者：
Guoqiang Shan;Zhi Wang;Lianqiu Zhou;Pin Du;Xiaoxiao Luo;Qiannian Wu;Lingyan Zhu
全氟烷基物质(PFAS)在人类日常摄入中已被广泛研究，用于评估潜在的健康风险。然而，关于全氟辛烷磺酸的异构体组成以及它们对人体异构体分布的影响，人们知之甚少。在这项研究中，我们用异构体分析方法调查了食品、自来水和室内粉尘等各种人体暴露基质中全氟辛烷磺酸的存在情况。中国说，天津市采集的接触基准物中以全氟辛烷磺酸(PFOS)和/或全氟辛酸(PFOA)为主。在鱼和肉中，线性(n-)全氟辛酸的富集率分别为92.2%和99.6%。尽管鱼的全氟辛烷磺酸含量(84.8%)高于工业全氟辛烷磺酸(约70%)，但肉类(63.1%)和蔬菜(58.5%)的全氟辛烷磺酸含量要低得多。膳食摄入量占普通人群估计每日摄入量(EDI)的99%。根据EDI和一室一级药代动力学模型，预测了全氟辛酸和全氟辛烷磺酸在人血清中的异构体分布。天津市居民EDI中n-全氟辛酸的异构体百分比(98.6%)与人血清中n-全氟辛酸的异构体百分比(预测：98.2%，先前测量：99.7%)相似。结果表明，人体对全氟辛酸的直接摄入量对其异构体的组成起着重要作用。对于全氟辛烷磺酸，预测的全氟辛烷磺酸(69.3%)远远高于之前在人血清中测得的值(59.2%)。这意味着，其他因素，如间接接触全氟辛烷磺酸前体和多种排泄途径，可能导致人体内n-全氟辛烷磺酸的百分比低于技术上的全氟辛烷磺酸。
Perfluoroalkyl substances (PFASs) have been well studied in human daily intake for assessment of potential health risks. However, little is known about the isomeric compositions of PFASs in daily intake and their impacts on isomeric profiles in humans. In this study, we investigated the occurrence of PFASs with isomeric analysis in various human exposure matrices including foodstuffs, tap water and indoor dust. Perfluorooctanesulfonate (PFOS) and/or perfluorooctanoate (PFOA) were predominant in these exposure matrices collected in Tianjin, China. In fish and meat, linear (n-) PFOA was enriched with a percentage of 92.2% and 99.6%, respectively. Althoughn-PFOS was higher in fish (84.8%) than in technical PFOS (ca. 70%), it was much lower in meat (63.1%) and vegetables (58.5%). Dietary intake contributed > 99% of the estimated daily intake (EDI) for the general population. The isomeric profiles of PFOA and PFOS in human serum were predicted based on the EDI and a one-compartment, first-order pharmacokinetic model. The isomeric percentage ofn-PFOA in the EDI (98.6%) was similar to that in human serum (predicted: 98.2%, previously measured: 99.7%) of Tianjin residents. The results suggest direct PFOA intake plays an important role in its isomeric compositions in humans. For PFOS, the predictedn-PFOS (69.3%) was much higher than the previously measured values (59.2%) in human serum. This implies that other factors, such as indirect exposure to PFOS precursors and multiple excretion pathways, may contribute to the lower percentage ofn-PFOS in humans than of technical PFOS.