Henoch Schönlein purpura associated with pulmonary adenocarcinoma.
Henoch Schönlein purpura associated with pulmonary adenocarcinoma.
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DOI：
10.1186/1752-1947-5-226
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发表时间：
2011-06-22
影响因子：
1
通讯作者：
Narita I
中科院分区：
文献类型：
--
作者：
Mifune D;Watanabe S;Kondo R;Wada Y;Moriyama H;Kagamu H;Yoshizawa H;Tetsuka T;Matsuyama A;Ito K;Narita I
Henoch-Schönlein紫癜是一种常见的儿童免疫球蛋白a介导的血管炎综合征。Henoch-Schönlein紫癜也可影响成人，可能与恶性肿瘤有关。我们报告的情况下，61岁的日本男子谁提出检查后，一个异常的阴影是由胸部x线检查。他被诊断为肺腺癌，第四期。腿部紫癜，腹痛，腹泻，血尿和蛋白尿出现。Henoch-Schönlein紫癜的诊断，根据临床症状和皮肤活检标本的组织学检查结果，显示血管炎和免疫球蛋白A沉积。我们的患者在成功的类固醇治疗Henoch-Schönlein紫癜后接受了吉西他滨化疗。虽然血液系统恶性肿瘤是众所周知的血管血管炎的原因，病例Henoch-Schönlein紫癜与肺腺癌是罕见的。我们的病人接受了皮质类固醇治疗，清除了紫癜和细胞毒性化疗的非小细胞肺癌。然而，他死于心脏填塞引起的心力衰竭。
Henoch-Schönlein purpura is a common immunoglobulin A-mediated vasculitis syndrome in children. Henoch-Schönlein purpura can also affect adults and is probably related to malignancy. We report the case of a 61-year-old Japanese man who presented for examination after an abnormal shadow was detected by chest radiography. He received a diagnosis of pulmonary adenocarcinoma, stage IV. Purpura on the legs, abdominal pain, diarrhea, hematuria and proteinuria developed at this time. Henoch-Schönlein purpura was diagnosed, base on the clinical symptoms and histological findings of biopsy specimens of the skin, which showed vasculitis with immunoglobulin A deposits. Our patient received chemotherapy with gemcitabine after successful steroid therapy for the Henoch-Schönlein purpura. Although hematological malignancies are well-known causes of vasculitides, cases of Henoch-Schönlein purpura associated with lung adenocarcinoma are rare. Our patient was treated with corticosteroid therapy, which cleared the purpura and cytotoxic chemotherapy for the non-small cell lung cancer. However, he died from heart failure due to cardiac tamponade.