Evaluation of cerebrovascular reserve using xenon-enhanced CT scanning in patients with symptomatic middle cerebral artery stenosis
Evaluation of cerebrovascular reserve using xenon-enhanced CT scanning in patients with symptomatic middle cerebral artery stenosis
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DOI：
10.1016/j.jocn.2013.04.038
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发表时间：
2014-02
影响因子：
2
通讯作者：
W. Cao;Xin Cheng;Hao-xiong Li;Liang Wang;Xiaolong Zhang;Q. Dong
中科院分区：
文献类型：
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作者：
W. Cao;Xin Cheng;Hao-xiong Li;Liang Wang;Xiaolong Zhang;Q. Dong
Cerebrovascular reserve (CVR) is an important prognostic factor in patients with major cerebral arterial steno-occlusive disease. However, few studies have examined CVR in symptomatic intracranial stenosis without ipsilateral extracranial internal carotid artery stenosis. This study sought to evaluate CVR in patients with symptomatic middle cerebral artery (MCA) stenosis using xenon-enhanced computed tomography (Xe/CT) with acetazolamide (ACZ) challenge. Twelve patients with symptomatic MCA stenosis were recruited. All patients were examined by Xe/CT to quantitatively measure resting cerebral blood flow (CBF) and received ACZ challenge to evaluate CVR. For resting CBF, no significant differences were found between the sides in four regions of interest. After the ACZ challenge test, the CVR was significantly different between hemispheres (ipsilateralversuscontralateral CVR: 12.9 ± 24.3%versus28.0 ± 16.8%, respectively;p= 0.005) and in the MCA territory (ipsilateralversuscontralateral CVR: 8.7 ± 24.7%versus29.3 ± 24%, respectively;p= 0.003). However, no significant differences in CVR were detected between cortical comparisons and white matter comparisons from the two sides. Thus, ACZ-challenge Xe/CT is useful for the measurement of CBF and CVR in these patients. Impaired CVR is an important characteristic of patients with symptomatic MCA stenosis.
