Relationships among cortisol (CRT), dehydroepiandrosterone-sulfate (DHEAS), and memory in a longitudinal study of healthy elderly men and women
Relationships among cortisol (CRT), dehydroepiandrosterone-sulfate (DHEAS), and memory in a longitudinal study of healthy elderly men and women
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DOI：
10.1016/s0197-4580(99)00052-4
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发表时间：
1999-05-01
影响因子：
4.2
通讯作者：
Sherwin, BB
中科院分区：
文献类型：
--
作者：
Carlson, LE;Sherwin, BB
在测试时间18个月(时间1和2),男性(n时间1 = 31日时间2 = 23),女性服用雌激素(时间2 n时间1 = 14日= 10),和女性雌激素吸毒者(n时间1 = 41岁,2 = 27),平均年龄为72.1和73.4年时间1和2,分别进行了一连串的神经心理学测试测量非文字记忆,视觉记忆,浓度/关注,语言流畅性和语义记忆。用放射免疫法测定两个试验时间血浆中CRT和DHEAS的水平。在两次测试中，男性的DHEAS水平都高于两组女性（p < 0.001），并且与未使用雌激素的女性相比，男性的DHEAS/CRT比率也更高（p < 0.05）。虽然两组间CRT水平均无差异，但未使用雌激素的妇女的CRT水平从时间1到时间2增加（p < 0.001）。在陈述性记忆的多项测试中，CRT水平较低的受试者表现优于CRT水平较高的受试者（p < 0.05）。在两次测试中，男性和雌激素使用者的Digit Span得分高于未使用雌激素的女性（p < 0.01），女性雌激素使用者的Backward Digit Span得分也高于未使用雌激素的女性（p < 0.05）。两组女性在类别检索上均优于男性（p < 0.01）。这些发现表明，老年男性和女性体内较高的CRT水平与较差的外显记忆功能有关；然而，这些结果没有提供任何证据表明DHEAS可以防止陈述性记忆随着年龄的增长而下降。(C) 1999 Elsevier Science Inc.；版权所有。
At test times 18 months apart (Time 1 and Time 2), men (n Time 1 = 31, Time 2 = 23), women estrogen-users (n Time 1 = 14, Time 2 = 10), and women estrogen non-users (n Time 1 = 41, Time 2 = 27), whose average age was 72.1 and 73.4 years at Time 1 and Time 2, respectively, were tested with a battery of neuropsychological tests measuring verbal memory, visual memory, concentration/attention, language fluency and semantic memory. Plasma levels of CRT and DHEAS were assayed by radioimmunoassay at both test times. The men had higher DHEAS levels than both groups of women at both test times (p < 0.001) and also had a higher DHEAS/CRT ratio compared to the estrogen non-users (p < 0.05). Although there were no group differences in CRT levels at either time, CRT levels increased in the estrogen non-using women from Time 1 to Time 2 (p < 0.001). Subjects with lower CRT levels performed better than those with higher levels on several tests of declarative memory (p < 0.05). Men and estrogen-users had higher Digit Span scores compared to female estrogen non-users at both test times (p < 0.01), and women estrogen-users also had higher Backward Digit Span scores than non-users (p < 0.05). Both groups of women performed better than men on Category Retrieval (p < 0.01). These findings suggest that higher CRT levels in elderly men and women are associated with poorer explicit memory functioning; however, these results failed to provide any evidence that DHEAS is protective against declarative memory decline with aging. (C) 1999 Elsevier Science Inc. All rights reserved.