Platelets as initiators and mediators of inflammation at the vessel wall.
Platelets as initiators and mediators of inflammation at the vessel wall.
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DOI：
10.1016/j.thromres.2010.10.019
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发表时间：
2011-05
影响因子：
7.5
通讯作者：
Morrell CN
中科院分区：
文献类型：
--
作者：
Shi G;Morrell CN
血小板是动态细胞，其活动超出血栓形成，包括在引发和维持血管炎症中的重要作用。血小板在许多生理和病理生理过程中的作用已被描述，如动脉粥样硬化、干细胞运输、肿瘤转移和关节炎。在完整发炎内皮部位的血小板活化有助于血管炎症和血管壁重塑。血小板在活化时分泌大量预先形成和合成的炎症介质，其可以发挥显著的局部和全身作用。本文就血小板源性介质在血管炎症和血管壁重塑中的作用作一综述。
Platelets are dynamic cells with activities that extend beyond thrombosis including an important role in initiating and sustaining vascular inflammation. A role for platelets has been described in many physiologic and pathophysiologic processes such as atherosclerosis, stem cell trafficking, tumor metastasis, and arthritis. Platelet activation at sites of an intact inflamed endothelium contributes to vascular inflammation and vascular wall remodeling. Platelets secrete a wide array of preformed and synthesized inflammatory mediators upon activation that can exert significant local and systemic effects. This review will focus on the role of platelet derived mediators in vascular inflammation and vascular wall remodeling.
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