Detecting circular RNAs: bioinformatic and experimental challenges.
Detecting circular RNAs: bioinformatic and experimental challenges.
复制标题
检测圆形RNA：生物信息学和实验挑战。
DOI：
10.1038/nrg.2016.114
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发表时间：
2016-10-14
期刊：
影响因子：
--
通讯作者：
Salzman J
中科院分区：
文献类型：
--
作者：
Szabo L;Salzman J
The pervasive expression of circular RNAs (circRNAs) is a recently discovered feature of gene expression in highly diverged eukaryotes. Numerous algorithms that are used to detect genome-wide circRNA expression from RNA sequencing (RNA-seq) data have been developed in the past few years, but there is little overlap in their predictions and no clear gold-standard method to assess the accuracy of these algorithms. We review sources of experimental and bioinformatic biases that complicate the accurate discovery of circRNAs and discuss statistical approaches to address these biases. We conclude with a discussion of the current experimental progress on the topic.
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