RELATIONSHIP BETWEEN PROTEIN ADSORPTIVE CAPACITY AND THE X-RAY-DIFFRACTION PATTERN OF ALUMINUM HYDROXIDE ADJUVANTS
RELATIONSHIP BETWEEN PROTEIN ADSORPTIVE CAPACITY AND THE X-RAY-DIFFRACTION PATTERN OF ALUMINUM HYDROXIDE ADJUVANTS
复制标题
DOI：
10.1016/0264-410x(94)90059-0
复制
发表时间：
1994-02-01
期刊：
影响因子：
5.5
通讯作者：
HEM, SL
中科院分区：
文献类型：
--
作者：
MASOOD, H;WHITE, JL;HEM, SL
氢氧化铝佐剂制备过程中的热处理影响佐剂的初级微晶尺寸。初级微晶尺寸可以通过X射线衍射图的（020）反射的线加宽来表征。以牛血清白蛋白为模型蛋白的蛋白质吸附研究揭示了白蛋白吸附量与X射线衍射图中（020）反射峰半高宽（WHH）之间的直接关系。
Thermal treatment during the preparation of aluminium hydroxide adjuvants affects the primary crystallite size of the adjuvant. The primary crystallite size can be characterized by the line broadening of the (020) reflection of the X-ray diffraction pattern. Studies of protein adsorption using bovine serum albumin as a model protein revealed a direct relationship between the albumin adsorptive capacity and the width at half height (WHH) of the (020) reflection in the X-ray diffraction pattern.