Advanced glycation end products are associated with sarcopenia in older women: aging marker dynamics
Advanced glycation end products are associated with sarcopenia in older women: aging marker dynamics
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DOI：
10.1080/08952841.2019.1697161
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发表时间：
2019-11-28
影响因子：
1.5
通讯作者：
Ohtori, Seiji
中科院分区：
文献类型：
--
作者：
Eguchi, Yawara;Toyoguchi, Toru;Ohtori, Seiji
本研究的目的是确定晚期糖基化终末产物（AGEs）的皮肤自发荧光（SAF），血清和尿液中的戊糖苷水平，血清同型半胱氨酸水平可以作为一个生物标志物，在老年妇女的肌肉减少症。参与者是70名老年妇女。AGEs戊糖苷、同型半胱氨酸和SAF被测量为老化标记物。这项研究表明，在衰老的生物标志物中，血清戊糖苷酶与非典型瘦体重的损失相关，可以作为肌肉减少症的生物标志物。此外，SAF和同型半胱氨酸值与年龄呈正相关，并彼此相关。
The aim of this study was to determine whether advanced glycation end products (AGEs) revealed by skin autofluorescence (SAF), serum and urine pentosidine level, and serum homocysteine level can serve as a biomarker for sarcopenia in older women. The participants were 70 elderly women. The AGEs pentosidine, homocysteine, and SAF were measured as aging markers. This study shows that among the biomarkers for aging, serum pentosidine correlates with a loss of appendicular lean mass and can serve as a biomarker for sarcopenia. Moreover, SAF and homocysteine values exhibited a positive correlation with age and correlated with each other.