The callipyge mutation and other genes that affect muscle hypertrophy in sheep
The callipyge mutation and other genes that affect muscle hypertrophy in sheep
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DOI：
10.1051/gse:2004032
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发表时间：
2005-01-01
影响因子：
4.1
通讯作者：
Charlier, C
中科院分区：
文献类型：
--
作者：
Cockett, NE;Smit, MA;Charlier, C
提高绵羊业务盈利能力的遗传战略一般集中在繁殖性状上。然而，绵羊中存在影响肌肉生长和发育的自然突变，在育种策略中利用这些突变有可能显着提高瘦肉质量。绵羊肌肉发育的最佳记录突变是callipyge（CLPG），它会导致出生后骨盆和腰部的肌肉肥大。增强骨骼肌生长也观察到在动物与Carwell（或肋眼肌肉）突变，和双肌肉表型已被记录的动物的Texel绵羊品种。然而，负责这些肌肉肥大表型在绵羊的实际突变尚未确定，这些表型的遗传基础的进一步表征将提供深入了解肌肉生长和身体组成的生物控制。
Genetic strategies to improve the profitability of sheep operations have generally focused on traits for reproduction. However, natural mutations exist in sheep that affect muscle growth and development, and the exploitation of these mutations in breeding strategies has the potential to significantly improve lamb-meat quality. The best-documented mutation for muscle development in sheep is callipyge (CLPG), which causes a postnatal muscle hypertrophy that is localized to the pelvic limbs and loin. Enhanced skeletal muscle growth is also observed in animals with the Carwell (or rib-eye muscling) mutation, and a double-muscling phenotype has been documented for animals of the Texel sheep breed. However, the actual mutations responsible for these muscular hypertrophy phenotypes in sheep have yet to be identified, and further characterization of the genetic basis for these phenotypes will provide insight into the biological control of muscle growth and body composition.