Recent Trends in the Use of Electrical Neuromodulation in Parkinson's Disease.
Recent Trends in the Use of Electrical Neuromodulation in Parkinson's Disease.
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DOI：
10.1007/s40473-018-0154-9
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发表时间：
2018
影响因子：
1.7
通讯作者：
Cagnan H
中科院分区：
文献类型：
--
作者：
Brittain JS;Cagnan H
这篇综述旨在综述神经调节的电形式的最新趋势，并具体应用于帕金森氏病(PD)。确定了新的趋势，突出了最先进的神经调节策略的协同效应，并提出了未来刺激效果改进的方向。脑深部刺激仍然是治疗帕金森病最常见和最有效的电刺激形式。有证据表明，经颅直流电刺激(TDC)最有可能影响疾病的运动症状，最显著的结果与康复有关。然而，由于其疗效弱、变异性大，其实用性受到限制，药物状态是影响疗效水平的关键因素。最近在经颅交流电刺激(TACS)方面的创新为研究提供了新的领域。我们对电流刺激的机制基础的理解正在进步，在这样做的同时，出现了一些趋势，这些趋势将引导未来的临床试验朝着更有效的方向发展。
This review aims to survey recent trends in electrical forms of neuromodulation, with a specific application to Parkinson’s disease (PD). Emerging trends are identified, highlighting synergies in state-of-the-art neuromodulation strategies, with directions for future improvements in stimulation efficacy suggested. Deep brain stimulation remains the most common and effective form of electrical stimulation for the treatment of PD. Evidence suggests that transcranial direct current stimulation (tDCS) most likely impacts the motor symptoms of the disease, with the most prominent results relating to rehabilitation. However, utility is limited due to its weak effects and high variability, with medication state a key confound for efficacy level. Recent innovations in transcranial alternating current stimulation (tACS) offer new areas for investigation. Our understanding of the mechanistic foundations of electrical current stimulation is advancing and as it does so, trends emerge which steer future clinical trials towards greater efficacy.