The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
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DOI：
10.1038/ni.2006
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发表时间：
2011-04-01
影响因子：
30.5
通讯作者：
Kallies, Axel
中科院分区：
文献类型：
--
作者：
Cretney, Erika;Xin, Annie;Kallies, Axel
调节性T细胞（T-reg细胞）是外周耐受所必需的。有证据表明，T-reg细胞可在外周采用特殊的分化程序，这些程序受通常与辅助性T细胞分化相关的转录因子控制。在此我们证明，转录因子Blimp - 1的表达定义了一群主要定位于黏膜部位并产生白细胞介素 - 10（IL - 10）的T - reg细胞。这些细胞产生IL - 10以及它们的组织内稳态都需要Blimp - 1。我们提供的证据表明，转录因子IRF4（而不是转录因子T - bet）对Blimp - 1的表达以及所有效应性T - reg细胞的分化至关重要。因此，我们的研究确定了一条导致获得T - reg细胞效应功能且需要IRF4和Blimp - 1两者的分化途径。
Regulatory T cells (T-reg cells) are required for peripheral tolerance. Evidence indicates that T-reg cells can adopt specialized differentiation programs in the periphery that are controlled by transcription factors usually associated with helper T cell differentiation. Here we demonstrate that expression of the transcription factor Blimp-1 defined a population of T-reg cells that localized mainly to mucosal sites and produced IL-10. Blimp-1 was required for IL-10 production by these cells and for their tissue homeostasis. We provide evidence that the transcription factor IRF4, but not the transcription factor T-bet, was essential for Blimp-1 expression and for the differentiation of all effector T-reg cells. Thus, our study defines a differentiation pathway that leads to the acquisition of T-reg cell effector functions and requires both IRF4 and Blimp-1.