Desmosomes: Essential contributors to an integrated intercellular junction network.
Desmosomes: Essential contributors to an integrated intercellular junction network.
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DOI：
10.12688/f1000research.20942.1
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Broussard, Joshua A
中科院分区：
文献类型：
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作者：
Green, Kathleen J;Jaiganesh, Avinash;Broussard, Joshua A
细胞间粘附连接的发展对于多细胞的进化和将细胞组织成具有离散室的复杂器官至关重要。脊椎动物细胞间连接有四种类型：桥粒连接、粘附连接、紧密连接和间隙连接。所有这些对胚胎层和器官的发育以及成体组织的稳态都是必不可少的。虽然每种连接类型都被定义为一个不同的实体，但现在很清楚，它们在物理上和功能上相互合作，以创建一个健壮且功能多样的系统。在进化过程中，桥粒最初出现在脊椎动物中，是作为质膜上高度特化的区域，在细胞间强粘附点与中间丝细胞骨架偶联。在这里，我们回顾了桥粒如何通过与现有的连接和细胞骨架网络的相互作用，赋予脊椎动物细胞和组织新的机械和信号特性。
The development of adhesive connections between cells was critical for the evolution of multicellularity and for organizing cells into complex organs with discrete compartments. Four types of intercellular junction are present in vertebrates: desmosomes, adherens junctions, tight junctions, and gap junctions. All are essential for the development of the embryonic layers and organs as well as adult tissue homeostasis. While each junction type is defined as a distinct entity, it is now clear that they cooperate physically and functionally to create a robust and functionally diverse system. During evolution, desmosomes first appeared in vertebrates as highly specialized regions at the plasma membrane that couple the intermediate filament cytoskeleton at points of strong cell-cell adhesion. Here, we review how desmosomes conferred new mechanical and signaling properties to vertebrate cells and tissues through their interactions with the existing junctional and cytoskeletal network.