Effects of prolactin on tyrosine hydroxylase activity of central dopaminergic neurons of male rats.
Effects of prolactin on tyrosine hydroxylase activity of central dopaminergic neurons of male rats.
复制标题
催乳素对雄性大鼠中枢多巴胺能神经元酪氨酸羟化酶活性的影响。
DOI：
10.1016/0014-2999(89)90361-0
复制
发表时间：
1989
影响因子：
5
通讯作者：
Ramirez,VD
中科院分区：
文献类型：
--
作者：
Chen,JC;Ramirez,VD
Previous work from our laboratory has indicated that ovine proclatin can produce a rapid stimulation (within 1 h) of dopamine release from nigrostriatal and mesolimbic dopaminergic neurons of male rats. In the present experiment we attempted to determine whether this effect of prolactin was a function of an increase in the activation of dopamine synthesis. To examine this possibility we used the drug NSD 1015. This drug is a decarboxylase inhibitor that leads to dopa accumulation and is used as an index of in vivo tyrosine hydroxylase activity. Our results demonstrated that ovine proclatin increased turnover of dopamine but had no effect upon tyrosine hydroxylase activation (up to 4 h) in both dorsal and ventral striatal dopaminergic neurons. In contrast, ovine prolacting had a clear effect (within 4 h) on tyrosine hydroxylase activity in mediobasal hypothalamic dopaminergic neurons. These results suggest that ovine prolactin can differentially alter synthesis/release processes of dopamine from these sites.
