H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa.
H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa.
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DOI：
10.1101/gr.196295.115
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发表时间：
2016-02
期刊：
影响因子：
7
通讯作者：
H3ABioNet Consortium
中科院分区：
文献类型：
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作者：
Mulder NJ;Adebiyi E;Alami R;Benkahla A;Brandful J;Doumbia S;Everett D;Fadlelmola FM;Gaboun F;Gaseitsiwe S;Ghazal H;Hazelhurst S;Hide W;Ibrahimi A;Jaufeerally Fakim Y;Jongeneel CV;Joubert F;Kassim S;Kayondo J;Kumuthini J;Lyantagaye S;Makani J;Mansour Alzohairy A;Masiga D;Moussa A;Nash O;Ouwe Missi Oukem-Boyer O;Owusu-Dabo E;Panji S;Patterton H;Radouani F;Sadki K;Seghrouchni F;Tastan Bishop Ö;Tiffin N;Ulenga N;H3ABioNet Consortium
由于新的高通量基因分型和测序技术以及改进的数据分析能力，基因组学技术在医学和生物医学研究中的应用日益普及。人类、动物、植物和微生物群中最大的遗传多样性发生在非洲，但非洲大陆的基因组研究成果有限。非洲人类遗传与健康（H3Africa）倡议的建立是为了推动非洲人类健康基因组研究的发展，并通过认识到生物信息学在这一过程中的关键作用，促进了H3ABioNet的建立，这是一个泛非洲的H3Africa生物信息学网络。非洲大陆生物信息学能力的局限性是造成高通量生物学研究缺乏显著产出的一个主要因素。虽然以前已经存在高质量的生物信息学团队，但大多数研究机构缺乏经验丰富的教师，无法培训和指导生物信息学学生。H3ABioNet旨在解决这一迫切需求，特别是在人类遗传学和基因组学领域，但连锁效应正在确保这扩展到生物信息学的其他领域。在这里，我们通过H3ABioNet描述了基因组学研究的出现和非洲生物信息学的发展。
The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping and sequencing technologies and improved data analysis capabilities. Some of the greatest genetic diversity among humans, animals, plants, and microbiota occurs in Africa, yet genomic research outputs from the continent are limited. The Human Heredity and Health in Africa (H3Africa) initiative was established to drive the development of genomic research for human health in Africa, and through recognition of the critical role of bioinformatics in this process, spurred the establishment of H3ABioNet, a pan-African bioinformatics network for H3Africa. The limitations in bioinformatics capacity on the continent have been a major contributory factor to the lack of notable outputs in high-throughput biology research. Although pockets of high-quality bioinformatics teams have existed previously, the majority of research institutions lack experienced faculty who can train and supervise bioinformatics students. H3ABioNet aims to address this dire need, specifically in the area of human genetics and genomics, but knock-on effects are ensuring this extends to other areas of bioinformatics. Here, we describe the emergence of genomics research and the development of bioinformatics in Africa through H3ABioNet.