Association of gut-related metabolites with outcome in acute heart failure
Association of gut-related metabolites with outcome in acute heart failure
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DOI：
10.1016/j.ahj.2021.01.006
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发表时间：
2021-01-26
影响因子：
4.8
通讯作者：
Suzuki, Toru
中科院分区：
文献类型：
--
作者：
Israr, Muhammad Zubair;Bernieh, Dennis;Suzuki, Toru
氧化三甲胺（TMAO）是一种肠道相关代谢物，与心力衰竭（HF）结局相关。然而，TMAO是一个复杂的代谢途径（即胆碱/肉毒碱）的最终产物，从未在HF中完全研究过。本研究调查了一组参与TMAO-胆碱/肉毒碱代谢途径的代谢物与急性HF patients.Methods结果的关系，总共分析了806例急性HF患者的血浆样本中的TMAO、三甲基赖氨酸、L-肉毒碱、乙酰-L-肉毒碱、γ-丁甜菜碱、巴豆甜菜碱、三甲胺、甜菜碱醛、胆碱、和甜菜碱。研究了30天和1年时全因死亡率（死亡）结局以及全因死亡率和/或HF导致的再住院（死亡/HF）复合结局的相关性。结果TMAO、三甲基赖氨酸、L-肉毒碱、乙酰-L-肉毒碱和γ-丁甜菜碱与30天时的死亡和死亡/HF相关（短期;风险比1.30-1.49，P
Background Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes. However, TMAO is the final product of a complex metabolic pathway (ie, choline/carnitine) that has never been entirely investigated in HF. The present study investigates a panel of metabolites involved in the TMAO-choline/carnitine metabolic pathway for their associations with outcome in acute HF patients.Methods In total, 806 plasma samples from acute HF patients were analyzed for TMAO, trimethyllysine, L-carnitine, acetyl-L-carnitine, gamma-butyrobetaine, crotonobetaine, trimethylamine, betaine aldehyde, choline, and betaine using a developed liquid chromatography-tandem mass spectrometry method. Associations with outcome of all-cause mortality (death) and a composite of all-cause mortality and/or rehospitalization caused by HF (death/HF) at 30 days and 1 year were investigated.Results TMAO, trimethyllysine, L-carnitine, acetyl-L-carnitine, and gamma-butyrobetaine were associated with death and death/HF at 30 days (short term; hazard ratio 1.30-1.49, P