TISSUE-BLOOD PARTITION-COEFFICIENT FOR XENON - TEMPERATURE AND HEMATOCRIT DEPENDENCE
TISSUE-BLOOD PARTITION-COEFFICIENT FOR XENON - TEMPERATURE AND HEMATOCRIT DEPENDENCE
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DOI：
10.1152/jappl.1980.49.2.178
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发表时间：
1980-01-01
影响因子：
3.3
通讯作者：
CHIEN, S
中科院分区：
文献类型：
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作者：
CHEN, RYZ;FAN, FC;CHIEN, S
在 37、27、20 和 4°C 下测定从狗获得的血浆 (Sp)、红细胞 (Sc) 和各种组织匀浆 (St) 中 133Xe 的奥斯特瓦尔德溶解度系数。 C 通过计算平衡后同一管中空气相和样品（液体、细胞或组织）的 133Xe 活性。对于所有组织，溶解度系数与温度成反比。 Sp、Sc 和 St 与绝对温度的倒数之间存在线性关系（阿累尼乌斯图）。由测得的Sp、Sc和St计算出的氙的红细胞-血浆(λ.cp)和组织-血浆(λ.tp)分配系数值与从阿累尼乌斯图的线性回归获得的预测值非常吻合。利用λcp、λtp和血细胞比容值，可以计算组织-血液分配系数(λtb)。这种类型的方法产生更准确的 lambda.tb 值，并有利于在异常体温以及血细胞比容值变化较大的情况下通过 Xe 冲洗进行血流研究。由于在低温下各种组织的λcp增加并且λtp减少，所以在低温下λtb较低。 Xe在各种组织中的溶解度的温度依赖性与脂质含量和蛋白质的量有关。
Ostwald''s solubility coefficients for 133Xe in plasma (Sp), red blood cells (Sc) and various tissue homogenates (St) obtained from the dogs were determined at 37, 27, 20 and 4.degree. C by counting the 133Xe activities of the air phase and the sample (liquid, cells or tissue) in the same tube following equilibration. For all tissues the solubility coefficient varies inversely with temperature. A linear relationship exists between Sp, Sc and St and the reciprocal of absolute temperature (Arrhenius plot). The values of red cell-plasma (.lambda.cp) and tissue-plasma (.lambda.tp) partition coefficients for xenon calculated from the measured Sp, Sc and St agree well with the predicted values obtained from the linear regressions of Arrhenius plots. With the use of .lambda.cp, .lambda.tp, and the hematocrit value, the tissue-blood partition coefficient (.lambda.tb) can be calculated. This type of approach yields more accurate .lambda.tb values and facilitates blood flow studies by Xe washout at abnormal body temperatures as well as in situations with a wide variation of hematocrit values. Because .lambda.cp increases and .lambda.tp for various tissues decreases at low temperature, .lambda.tb is lower in hypothermia. The temperature dependence of Xe solubility in various tissues is related to lipid content and amount of proteins.