Metal content of saliva of patients with and without metal restorations.
Metal content of saliva of patients with and without metal restorations.
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DOI：
10.1007/s00784-004-0281-4
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发表时间：
2004-12-01
影响因子：
3.4
通讯作者：
Schmalz, G
中科院分区：
文献类型：
--
作者：
Garhammer, P;Hiller, K-A;Schmalz, G
许多体外研究证实了牙科合金的腐蚀性。然而，体内腐蚀研究（例如记录金属离子释放到唾液中）很少，并且缺乏有关唾液金属含量测量可重复性的数据。本研究检查了有和没有金属中毒的患者唾液中的金属含量，并评估了这些数据的可重复性。每个病人的口腔铸造合金的组成进行了分析，使用能量色散X射线分析的金属活检标本，并进行比较，在唾液中发现的金属。使用原子吸收光谱法进行唾液分析。化学分析包括金属Ag、Au、Co、Cr、Cu、Fe、Ga、In、Ni、Pd、Pt、Sn和Zn。在没有金属沉淀的患者的唾液中发现了金属Ag、Cr、Cu、Fe、Ni和Zn，但是这些数据显示了每个患者连续进行的样品之间的金属含量的统计学显著差异。在唾液中发现了Ag、Au、Cr、Cu、Fe、Ni和Zn等金属元素，其浓度高于对照组。在77%的病例中，在患者的唾液中发现了至少一种修复体金属。然而，在不同时间采集的同一患者的重复样本之间的金属含量显示出统计学显著差异。唾液中的金属含量受口内金属沉积的影响，但目前的数据并不支持它是牙科合金释放的金属全身暴露的可靠指标。
Many in vitro studies have confirmed the corrosion of dental alloys. However, in vivo corrosion studies, for example, recording of the release of metal ions into saliva, are scarce, and data on the repeatability of the metal content measurements of saliva are lacking. The present study examined the metal content of saliva of patients with and without metal restorations and assessed the repeatability of these data. The composition of each patient's oral cast alloys was analyzed using the energy-dispersive X-ray analysis of metal biopsy specimens and was compared to the metals found in saliva. Saliva analysis was performed using atomic absorption spectroscopy. Chemical analysis comprised the metals Ag, Au, Co, Cr, Cu, Fe, Ga, In, Ni, Pd, Pt, Sn, and Zn. The metals Ag, Cr, Cu, Fe, Ni, and Zn were found in saliva of patients without metal restorations, but these data showed statistically significant differences in the metal content between consecutively performed samples per patient. The metals Ag, Au, Cr, Cu, Fe, Ni, and Zn were identified in saliva of patients with metal restorations being higher in concentration than in control patients. In 77% of the cases at least one metal of the restoration was found in the patient's saliva. However, the metal content showed statistically significant differences between replicate samples of the same patient taken at different times. The metal content of saliva is affected among other things by intraoral metal restorations, but present data do not support the idea that it is a reliable indicator for the systemic exposure to metals released from dental alloys.