Bilateral Wilms Tumors Treated According to the Japan Wilms Tumor Study Group Protocol
Bilateral Wilms Tumors Treated According to the Japan Wilms Tumor Study Group Protocol
复制标题
DOI：
10.1002/pbc.24979
复制
发表时间：
2014-07-01
影响因子：
3.2
通讯作者：
Fukuzawa, Masahiro
中科院分区：
文献类型：
--
作者：
Oue, Takaharu;Koshinaga, Tsugumichi;Fukuzawa, Masahiro
背景：患有弥漫性桥脑胶质瘤（DIPG）的儿童预后一直不佳，放射治疗（RT）是唯一暂时有效的治疗方法。在这项回顾性分析中，我们研究了从诊断到开始RT的时间对DIPG儿童的无事件生存期（EFS）和总生存期（OS）的影响。方法分析1999年4月至2009年9月在一家机构接受RT治疗的DIPG患儿（n = 95）的记录。RT的剂量为54.0-55.8戈伊，每次1.8戈伊，并对儿童进行前瞻性随访。通过考克斯比例风险模型评估性别、种族、治疗过程中中断、诊断时年龄、诊断前症状持续时间、使用基于方案的化疗以及从诊断到开始RT的时间对EFS和OS的影响。结果时间作为一个连续变量，从诊断开始RT不影响结果。时间二分法，
Background Children with diffuse intrinsic pontine glioma (DIPG) continue to have poor outcomes, and radiotherapy (RT) is the only temporarily effective treatment. In this retrospective analysis, we studied the effect of time from diagnosis to start of RT on event-free survival (EFS) and overall survival (OS) in children with DIPG. Methods Records of children (n = 95) with DIPG treated with RT at a single institution between April 1999 and September 2009 were analyzed. RT was delivered at doses of 54.0-55.8 Gy at 1.8 Gy per fraction, and children were followed prospectively. The effect of gender, race, interruption during treatment course, age at diagnosis, duration of symptoms prior to diagnosis, use of protocol-based chemotherapy, and time from diagnosis to initiation of RT on EFS and OS was assessed by the Cox proportional hazards model. Results Time as a continuous variable from diagnosis to start of RT did not affect outcome. Time dichotomized to