Genotypic-specific heat shock response of vector susceptibility to Schistosoma mansoni.
Genotypic-specific heat shock response of vector susceptibility to Schistosoma mansoni.
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曼氏血吸虫媒介易感性的基因型特异性热休克反应。
DOI：
10.1002/ecs2.4207
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Steinauer,MichelleL
中科院分区：
文献类型：
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作者：
Spaan,JohannieM;Leavitt,Nathaniel;Shen,Jessica;Bundy,Taylor;Burrows,Lillian;Ingram,Christopher;Maehara,ThomasR;Ndungu,Ibrahim;Mutuku,Martin;Owino,George;Odiere,Maurice;Steinauer,MichelleL
生物体容易受到热应力的影响，这会导致多种生理结果。先前的研究表明，一种重要的人类病原体曼氏血吸虫的蜗牛载体（光滑双脐螺）在短时间暴露于低至31°C的热应激后从抗性恢复为易感性;然而，由于实验室和蜗牛遗传系之间缺乏可复制性，人们假设这种效应是基因型依赖的。本文研究了热休克对两种媒介钉螺抗性的影响。glabrata和苏丹双脐藻（Biomphalaria sudanica）。我们使用了三种不同的近交实验室蜗牛品系，以及来自肯尼亚维多利亚湖（血吸虫病传播水平较高的地区）的F1代现场收集的蜗牛。我们的研究结果表明，热休克对B。glabrata，这种反应是基因型特异性的。我们没有发现热休克对乙型肝炎病毒感染率有影响的证据。苏丹或关于任一种蜗牛的感染强度（传染阶段脱落的数量）。这种受环境影响的防御反应强调了在气候变化下确定感染动态时考虑蜗牛和寄生虫基因型之间这种独特相互作用的重要性。
Living organisms are vulnerable to thermal stress, which causes a diversity of physiological outcomes. Previous work has shown that the snail vectors (Biomphalaria glabrata) of an important human pathogen,Schistosoma mansoni, revert from resistant to susceptible after short exposure to a heat stress as low as 31°C; however, due to lack of replicability among labs and genetic lines of snails, it has been hypothesized that this effect is genotype dependent. We examined the effects of heat shock on the resistance of two species of snail vectors includingB. glabrataandBiomphalaria sudanica. We used three different inbred laboratory snail lines in addition to the F1 generation of field‐collected snails from Lake Victoria, Kenya, an area with high levels of schistosomiasis transmission. Our results showed marginal effects of heat shock on prevalence of infection inB. glabrata, and that this response was genotype specific. We found no evidence of a heat shock effect on prevalence of infection inB. sudanicaor on intensity of infection (number of infectious stages shed) in either snail species. Such environmentally influenced defense responses stress the importance of considering this unique interaction between snail and parasite genotypes in determining infection dynamics under climate changes.