Relative biological effectiveness of proton medical beam at Moscow synchrotron determined by the Chinese hamster cells assay.
Relative biological effectiveness of proton medical beam at Moscow synchrotron determined by the Chinese hamster cells assay.
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通过中国仓鼠细胞测定确定莫斯科同步加速器质子医疗束的相对生物有效性。
DOI：
10.1016/0360-3016(94)00381-t
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
L. V. Zinovyeva
中科院分区：
文献类型：
--
作者：
P. N. Yashkin;D. Silin;Vladmir A. Zolotov;V. I. Kostjuchenko;Dimitry F. Nichiporov;T. P. Feoktistova;K. S. Martirosov;Yelizaveta I. Minakova;V. Khoroshkov;Pavel B. Polonski;L. V. Zinovyeva
结果根据线性回归模型，在37%生存水平下，束流入口处的平均RBE值为1.10 ± 0.04，SOBP中心处的平均RBE值为1.14 ± 0.05。使用线性二次模型获得的10%和37%存活水平的RBE值在束入口处分别为1.09和1.07，在SOBP中心处分别为1.07和1.08。平均值约为1.10;（B）质子在放射生物学上比60 Co γ射线更有效;以及（c）医用射束的高脉冲剂量率不会显著影响射束的生物效应。
ResultsAccording to the linear regression model, mean RBE values at 37% survival level were found to be 1.10+/-0.04 at the beam entry and 1.14+/-0.05 in the center of SOBP. Values of RBE obtained using the linear-quadratic model for 10% and 37% survival levels were 1.09 and 1.07, respectively, at the beam entry and 1.07 and 1.08, respectively, in the center of SOBP.ConclusionsThe data obtained indicate that (a) the RBE values at the entry of the unmodulated beam and at the center of the SOBP are in close agreement, with an average of about 1.10;(b) protons are radiobiologically somewhat more effective than 60Co gamma rays; and,(c) high pulse dose rate of the medical beam does not significantly affect biological effects of the beam.