Associations of the fatty liver and hepatic steatosis indices with risk of cardiovascular disease: Interrelationship with age
Associations of the fatty liver and hepatic steatosis indices with risk of cardiovascular disease: Interrelationship with age
复制标题
DOI：
10.1016/j.cca.2017.01.008
复制
发表时间：
2017-03-01
影响因子：
5
通讯作者：
Dullaart, Robin P. F.
中科院分区：
文献类型：
--
作者：
Kunutsor, Setor K.;Bakker, Stephan J. L.;Dullaart, Robin P. F.
背景资料：脂肪肝指数（FLI）和肝性脂肪变性指数（HSI）是基于生物标志物的算法，作为非酒精性脂肪肝（NAFLD）的替代指标。我们评估了FLI和HSI与心血管疾病（CVD）risk.Materials and Methods的关联：在基线时估计FLI和HSI在PREVEND队列，涉及6340名参与者，年龄在28-75岁之间，没有预先存在的CVD.Results：在一个中位数为10.5年的随访期间，631 CVD事件发生。在年龄和性别校正的分析中，比较FLI ≥ 60与FLI < 30的CVD风险比（HR）（95%CI）为1.53（1.25-1.88）;在校正常规心血管危险因素后，其降低至0.89（0.70-1.13）。在对潜在混杂因素0.85（0.65-1.11）进行额外调整后，相关性仍然不存在。HSI > 36与HSI < 30比较，相应的调整HR分别为1.29（1.02-1.65）、0.84（0.65-1.09）和0.79（0.55-1.13）。亚组分析表明，在年轻的参与者（= 50岁）的两个指数（P为所有的互动= 0.001）。结论：目前的数据表明，年龄的相互作用NAFLD（FLI或HSI评估）与心血管疾病的风险在一般高加索人群的关联。(C)2017爱思唯尔B. V.保留所有权利。
Background: The fatty liver index (FLI) and the hepatic steatosis index (HSI), are biomarker-based algorithms developed as proxies for non-alcoholic fatty liver disease (NAFLD). We assessed associations of FLI and HSI with cardiovascular disease (CVD) risk.Materials and methods: The FLI and HSI were estimated at baseline in the PREVEND cohort involving 6340 participants aged 28-75 years without pre-existing CVD.Results: During a median follow-up of 10.5 years, 631 CVD events occurred. In age-and sex-adjusted analysis, the hazard ratio (HR) (95% CI) for CVD comparing FLI >= 60 versus FLI < 30 was 1.53 (1.25-1.88); which was attenuated to 0.89 (0.70-1.13) on adjustment for conventional cardiovascular risk factors. The association remained absent after additional adjustment for potential confounders 0.85 (0.65-1.11). Comparing HSI > 36 versus HSI < 30, the corresponding adjusted HRs were 1.29 (1.02-1.65), 0.84 (0.65-1.09) and 0.79 (0.55-1.13) respectively. Subgroup analyses suggested a positive association in younger participants (= 50 years) for both indices (P for interaction for all = 0.001).Conclusion: Current data suggest age interactions in the association of NAFLD (as assessed by FLI or HSI) with CVD risk in a general Caucasian population. (C) 2017 Elsevier B.V. All rights reserved.