C–F bond functionalizations of trifluoromethyl groups via radical intermediates
C–F bond functionalizations of trifluoromethyl groups via radical intermediates
复制标题
DOI：
10.1016/j.cclet.2021.08.043
复制
发表时间：
2021-08
影响因子：
9.1
通讯作者：
Tesfaye Tebeka Simur;T. Ye;You-Jie Yu;Feng-Lian Zhang;Yi‐Feng Wang
中科院分区：
文献类型：
--
作者：
Tesfaye Tebeka Simur;T. Ye;You-Jie Yu;Feng-Lian Zhang;Yi‐Feng Wang
Selective functionalization of C–F bonds in trifluoromethyl groups has recently received a growing interest, as it offers atom- and step-economic pathways to access highly valuable mono- and difluoroalkyl-substituted organic molecules using simple and inexpensive trifluoromethyl sources as the starting materials. In this regard, impressive progress has been made on the defluorinative functionalization reactions that proceedviaradical intermediates. Nevertheless, it is still a great challenge to precisely control the defluorination process, due to the continuous decrease of the C–F bond strength after the replacement of one or two fluorine atoms with various functionalities. This review article is aimed to provide a brief overview of recently reported methods used to functionalize C–F bonds of CF3groupsviaradical intermediates. An emphasis is placed on the discussion of mechanistic aspects and synthetic applications
