Antibodies to rotaviruses in chickens' eggs: a potential source of antiviral immunoglobulins suitable for human consumption.
Antibodies to rotaviruses in chickens' eggs: a potential source of antiviral immunoglobulins suitable for human consumption.
复制标题
DOI：
10.1542/peds.81.2.291
复制
发表时间：
1988-02
期刊：
影响因子：
8
通讯作者：
R. Yolken;F. Leister;S. Wee;R. Miskuff;S. Vonderfecht
中科院分区：
文献类型：
--
作者：
R. Yolken;F. Leister;S. Wee;R. Miskuff;S. Vonderfecht
调查了市售鸡蛋和适合人类食用的蛋制品中人轮状病毒抗体的流行情况。几乎所有单个鸡蛋和巴氏消毒池蛋制剂的蛋黄都含有抗轮状病毒抗体，可通过酶免疫测定系统检测到。此外，鸡蛋和鸡蛋制剂能够抑制组织培养中两株轮状病毒的生长。层析研究表明，抗原结合活性主要局限于蛋黄的免疫球蛋白部分。用纯化的轮状病毒制剂免疫母鸡可提高鸡蛋中的抗体水平，从免疫母鸡的鸡蛋中分离出的免疫球蛋白可防止实验感染动物发生轮状病毒胃肠炎。鸡蛋制剂可作为适合婴幼儿食用的抗病毒抗体的实际来源。
The prevalence of antibodies to human rotaviruses in commercially available eggs and egg products that are suitable for human consumption was investigated. The yolks of virtually all of the individual eggs and pasteurized pooled egg preparations contain antirotavirus antibodies detectable by means of enzyme immunoassay systems. Also, the eggs and egg preparations are capable of inhibiting the growth of two strains of rotaviruses in tissue culture. Chromatographic studies indicated that the antigen-binding activity is limited largely to the immunoglobulin fractions of the egg yolks. The antibody levels in eggs can be increased by the immunization of hens with purified rotavirus preparations, and the immunoglobulins isolated from the eggs of immunized hens can prevent the development of rotavirus gastroenteritis in experimentally infected animals. Egg preparations might serve as a practical source of antiviral antibodies suitable for consumption by infants and young children.