Optical coherence tomography angiography in juvenile open angle glaucoma: correlation between structure and perfusion
Optical coherence tomography angiography in juvenile open angle glaucoma: correlation between structure and perfusion
复制标题
DOI：
10.1007/s10792-020-01643-7
复制
发表时间：
2020-11-13
影响因子：
1.6
通讯作者：
Hassan, Lameece M.
中科院分区：
文献类型：
--
作者：
Abdelrahman, Ahmed M.;Eltanamly, Rasha M.;Hassan, Lameece M.
目的青少年开角型青光眼(JOAG)是40岁以下青光眼的一种。只有少数研究评估了JOAG的血管灌注量，并将其与结构损伤联系起来。本研究的目的是通过光学相干断层血管成像(OCTA)检测JOAG的血管灌注量，并将其与以视网膜神经纤维层(RNFL)变薄为代表的结构损伤相关联。方法对JOAG患者25只眼进行横断面观察研究。所有患者均行全眼OCTA检查，测量RNFL厚度、视乳头周围血管密度及视盘血管密度等参数。结果平均上、下RNFL厚度分别为69.4(+/-22.1)和70.4(+/-25.6)mm，乳头周围和视盘血管密度分别为38.2(+/-10)和39.1(+/-12)%，上、下血管密度分别为38.1(+/-10.5)和38.2(+/-9.7)%。上、下RNFL厚度与乳头状区、视盘血管密度、上、下血管密度呈显著正相关(p<；0.001)。结论JOAG患者的OCTA参数与结构损伤密切相关。OCTA可作为诊断和评估JOAG进展的有用工具，并可用作预后指标，从而填补其他评估方法中存在的缺陷和空白。
Purpose Juvenile open angle glaucoma (JOAG) is a type of glaucoma that occurs in patients younger than 40 years. Only a few studies have assessed vascular perfusion in JOAG and correlated it with structural damage. The aim of this study is to investigate vascular perfusion in JOAG by optical coherence tomography angiography (OCTA) and correlate it with structural damage, represented by retinal nerve fiber layer (RNFL) thinning. Methods This is a cross-sectional observational study of 25 eyes of patients with JOAG. All patients underwent full ocular examination and scanning by OCTA to measure parameters such as RNFL thickness, peripapillary and disk vascular density. Results Average superior and inferior RNFL thicknesses were 69.4 (+/- 22.1) and 70.4 (+/- 25.6) mu m, whereas peripapillary and disk vascular densities were 38.2(+/- 10), and 39.1(+/- 12) % and superior and inferior vascular densities were 38.1(+/- 10.5) and 38.2(+/- 9.7) %. A strong positive correlation was found between the superior and inferior RNFL thickness and the vascular density of the peripapillary region, the disk and the superior and inferior vascular densities (p < 0.001 for all). Conclusion OCTA parameters are strongly correlated with structural damage in JOAG patients. OCTA can serve as a helpful tool in the diagnosis and assessment of progression in JOAG and be utilized as a prognostic indicator, thus filling the defects and gaps present in other methods of assessment.