Interleukin-8 promotes cell migration via CXCR1 and CXCR2 in liver cancer
Interleukin-8 promotes cell migration via CXCR1 and CXCR2 in liver cancer
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DOI：
10.3892/ol.2019.10735
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发表时间：
2019-10-01
期刊：
影响因子：
2.9
通讯作者：
Shen, Jilu
中科院分区：
文献类型：
--
作者：
Bi, Huijuan;Zhang, Yu;Shen, Jilu
肝癌（Liver cancer，LC）是世界范围内最常见的恶性肿瘤之一，因其高发病率和高死亡率而臭名昭著。白细胞介素-8（IL-8）是CXC趋化因子家族的重要成员，最初被分类为有效的中性粒细胞趋化因子，已被证明通过与其受体的相互作用在炎症、肿瘤生长、侵袭和转移中起重要作用。然而，IL-8及其受体CXC趋化因子受体（CXCR）1和CXCR 2在肝癌进展中的表达和功能作用仍有待充分阐明。本研究发现，肝癌患者外周血单个核细胞IL-8、CXCR 1和CXCR 2的mRNA水平均高于肝硬化患者和正常对照组（P
Liver cancer (LC), which is one of the most common types of cancer worldwide, is notorious for its high morbidity and mortality rates. Interleukin-8 (IL-8), an important member of the CXC chemokine family that was originally classified as a potent neutrophil chemoattractant, has been shown to serve an important role in inflammation, tumor growth, invasion and metastasis through interactions with its receptors. However, the expression and functional roles of IL-8 and its receptors, CXC chemokine receptor (CXCR) 1 and CXCR2 in the progression of liver cancer remain to be fully elucidated. In the present study, it was shown that the mRNA levels of IL-8, CXCR1 and CXCR2 were increased in peripheral blood mononuclear cells from patients with liver cancer compared with those from patients with cirrhosis or normal controls (P