Optic Nerve Head and Retinal Nerve Fiber Layer Differences Between Caribbean Black and African American Patients as Measured by Spectral Domain OCT.
Optic Nerve Head and Retinal Nerve Fiber Layer Differences Between Caribbean Black and African American Patients as Measured by Spectral Domain OCT.
复制标题
通过谱域 OCT 测量加勒比黑人和非裔美国患者之间的视神经头和视网膜神经纤维层差异。
DOI：
10.1097/ijg.0000000000000010
复制
发表时间：
2015
影响因子：
2
通讯作者：
Blumberg,DanaM
中科院分区：
文献类型：
--
作者：
Rao,Rohini;Dhrami-Gavazi,Elona;Al-Aswad,Lama;Ciarleglio,Adam;Cioffi,GeorgeA;Blumberg,DanaM
Purpose:There are well-established differences in optic nerve morphology between patients of African and European descent. Spectral domain optical coherence tomography (OCT) scanning has demonstrated these differences with respect to optic disc area (DA), average cup-disc ratio, cup volume, and nerve fiber layer thickness. However, the term “African descent” describes a heterogenous group with considerable variability. This study evaluates differences in optic nerve and retinal nerve fiber layer (RNFL) parameters as measured by Cirrus HD-OCT between Caribbean black and African American patients.Design and Methods:A total of 25 African American subjects and 25 Caribbean black subjects with normal ocular examinations were consecutively recruited to this study. All patients received imaging of the optic nerve and nerve fiber layer with Cirrus HD-OCT. Optic nerve and RNFL parameters were evaluated for statistically significant differences using a t test. A mixed effect model for correlated data was then created to adjust outcome variables for (1) repeated measures and (2) optic nerve size. Two one-sided t tests were then utilized to determine equivalence.Results:After adjustment for DA, RNFL thickness, cup volume, DA, inferior nerve fiber layer, and vertical cup-disc ratio demonstrated statistically significant equivalence between the 2 groups (P value< 0.05). The superior nerve fiber layer quadrant was significantly different between the 2 groups and may merit further investigation.Conclusions:Findings of this study suggest that optic nerve and RNFL morphology is markedly similar between Caribbean blacks and African Americans once adjusted for optic nerve size but cannot be considered equivalent in all measures, particularly in the superior nerve fiber layer.BACKGROUNDGlaucoma is a leading cause of blindness, causing progressive, irreversible loss of vision, initially affecting the peripheral vision but slowly advancing to central vision loss. 1–3 Although the vision loss of glaucoma is irreversible, disease progression can be slowed or halted with appropriate medical management. The diagnosis of glaucoma is based on characteristic changes of the optic nerve as compared with a presumed “normal” appearance. However, well-characterized differences in normal optic nerve morphology among different racial groups have been well described. 4, 5 The Baltimore Eye Survey found a 12% larger mean optic disc area (DA) in the African American population, 6 and an analysis of postmortem eyes revealed that African descent patients have larger optic discs when compared with European-derived patients. 7 Comparisons between African-derived and European-derived patients using spectral domain optical coherence tomography (OCT) have demonstrated differences with respect to optic DA, average cup-disc ratio (ACDR), cup volume (CV), and nerve fiber layer thickness (RNFL). 8
