VioE, a prodeoxyviolacein synthase involved in violacein biosynthesis, is responsible for intramolecular indole rearrangement
VioE, a prodeoxyviolacein synthase involved in violacein biosynthesis, is responsible for intramolecular indole rearrangement
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DOI：
10.1016/j.tetlet.2007.02.062
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发表时间：
2007-04-16
影响因子：
1.8
通讯作者：
Onaka, Hiroyasu
中科院分区：
文献类型：
--
作者：
Asamizu, Shumpei;Kato, Yasuo;Onaka, Hiroyasu
Indole-3-pyruvic Acid 通过新型酶 VioE 转化为原脱氧紫色菌素，该酶参与紫色色杆菌 ATCC12472 中紫色菌素生物合成途径。 VioE 催化新生化合物的脱羧和吲哚环重排，该新生化合物是在色吡咯酸合酶（VioB 或 StaD）的作用下由吲哚-3-丙酮酸和 NH4+ 产生的，最终反应生成脱氧紫色菌素原。 (c) 2007 Elsevier Ltd. 保留所有权利。
Indole-3-pyruvic acid is transformed to prodeoxyviolacein by the novel enzyme VioE, which is involved in the violacein biosynthetic pathway in Chromobacterium violaceum ATCC12472. VioE catalyzes the decarboxylation and indole-ring rearrangement of a nascent compound that is produced from indole-3-pyruvic acid and NH4+ by the action of chromopyrrolic acid synthase (VioB or StaD), and ultimately the reaction yields prodeoxyviolacein. (c) 2007 Elsevier Ltd. All rights reserved.