Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs.
Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs.
复制标题
选择膳食脂肪酸可减轻猪急性肺损伤期间的心肺功能障碍。
DOI：
10.1152/ajpheart.1995.269.6.h2090
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
DeMichele,SJ
中科院分区：
文献类型：
--
作者：
Murray,MJ;Kumar,M;Gregory,TJ;Banks,PL;Tazelaar,HD;DeMichele,SJ
我们研究了用二十碳五烯酸（EPA）和γ-亚麻酸（γ-LA）（分别是三烯酸和单烯酸类二十烷酸的前体）替代亚油酸（LA）对急性肺损伤（ALI）的影响。将三组（n = 8/组）猪饲喂含有LA（饮食A）、EPA（饮食B）或EPA+ γ-LA（饮食C）的肠内饮食8天。然后用0.1 mg/kg的大肠杆菌内毒素推注诱导ALI，随后连续输注4 h（0.075 mg.kg-1.h-1）。测定肺动脉和毛细血管楔压、心脏指数（CI）、动脉血气、动脉血氧含量和血浆血栓素B2（TxB 2）。在喂食饲料A的动物中，动脉PO 2在20分钟时降低。饲料B和C减弱了这种变化。EPA-和EPA + γ-LA-丰富的饮食减弱了20分钟时O2输送的下降，仅EPA+ γ-LA-丰富的饮食在整个4小时研究期间持续改善。O2输送的改善不仅是由于动脉PO 2的改善，还由于饲喂饲料B和C的动物在20分钟时以及饲喂饲料C的动物在整个4小时研究期间的CI维持。在4小时，TxB 2增加10倍以上的动物喂养的饮食A，而在动物喂养的饮食B和C的增加只有3倍。喂食饲料B和C的动物中TxB 2水平的这些降低与在喂食饲料A的动物中内毒素输注后20分钟观察到的肺血管阻力增加的减弱相关。这些数据表明，专门的肠内饮食富含EPA+ γ-LA改善气体交换和O2的输送，大概是部分通过修改TxB 2的生产与肺血管阻力的降低和CI的增加，在ALI。
We examined the effect of substituting linoleic acid (LA) with eicosapentaenoic acid (EPA) and gamma-linolenic acid (gamma-LA), precursors of trienoic and monoenoic eicosanoids, respectively, on acute lung injury (ALI). Three groups (n = 8/group) of pigs were fed enteral diets containing LA (diet A), EPA (diet B), or EPA+gamma-LA (diet C) for 8 days. ALI was then induced with a 0.1 mg/kg bolus of Escherichia coli endotoxin followed by a continuous infusion for 4 h (0.075 mg.kg-1.h-1). Pulmonary arterial and capillary wedge pressures, cardiac index (CI), arterial blood gases, arterial O2 content, and plasma thromboxane B2 (TxB2) were measured. Arterial PO2 decreased at 20 min in animals fed diet A. This change was attenuated with diets B and C. The EPA- and EPA + gamma-LA-enriched diets attenuated the fall in O2 delivery at 20 min, an improvement that was sustained throughout the 4-h study period with the EPA+gamma-LA-enriched diet only. This improvement in O2 delivery was due not only to the improved arterial PO2, but also to the maintenance of CI at 20 min in animals fed diets B and C and throughout the 4-h study period in animals fed diet C. At 4 h, TxB2 increased 10-fold over baseline in animals fed diet A, whereas in animals fed diets B and C the increase was only 3-fold. These decreased TxB2 levels in animals fed diets B and C correlate with an attenuation in the increase in pulmonary vascular resistance that was observed at 20 min after endotoxin infusion in animals fed diet A. These data suggest that specialized enteral diets enriched in EPA+gamma-LA improve gas exchange and O2 delivery, presumably in part through a modification of TxB2 production with a decrease in pulmonary vascular resistance and an increase in CI, during ALI.