Polyphenolic Compounds and Intestinal Transfer
Polyphenolic Compounds and Intestinal Transfer
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多酚化合物和肠道转移
作者：
D. Hand;P. A. Sanford;D. Smyth
根皮素及其苷元根皮素影响己糖在许多组织中的转移，这是公认的。最近，Forsling和Widdas 1表明，酚酞可引起人红细胞易化葡萄糖转移的竞争性抑制。鉴于其通便作用，有必要测试酚酞是否也影响肠道转移机制。与此同时，利用这个机会测试了另一种多酚化合物酚红（酚磺酞），这是一种已知由肾小管转移的类似结构的分子。这些化合物的化学式如图1所示。
IT is well established that phlorrhizin and its aglycone phloretin affect hexose transfer in a number of tissues. Recently Forsling and Widdas1 showed that phenolphthalein caused competitive inhibition of facilitated glucose transfer in human erythrocytes. In view of its purgative action, it was of interest to test whether phenolphthalein also affected intestinal transfer mechanisms. At the same time the opportunity was taken to test another poly-phenolic compound phenol red (phenolsulphonphthalein), a molecule of similar structure which is known to be transferred by the renal tubule. The formulae of these compounds are shown in Fig. 1.