Intraglomerular hypertension: implications and drug treatment.
Intraglomerular hypertension: implications and drug treatment.
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肾小球内高血压：影响和药物治疗。
DOI：
10.1146/annurev.me.39.020188.001331
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发表时间：
1988
影响因子：
10.5
通讯作者：
Brenner,BM
中科院分区：
文献类型：
--
作者：
Anderson,S;Brenner,BM
全身性高血压既是进行性肾病的原因，也是其结果。最近的实验研究表明，全身和肾小球毛细血管高压不一定伴随，治疗干预可能独立影响全身和肾小球压力。控制肾小球毛细血管高压的治疗干预措施可以防止进行性肾损伤，即使存在持续的全身性高血压。相反，控制全身高血压而非肾小球高血压的治疗并不能保护肾脏免受持续损害。因此，如果抗高血压治疗要有效预防肾损伤的进展，则必须控制肾小球内高血压。
Systemic hypertension is both cause and consequence of progressive renal disease. Recent experimental studies indicate that systemic and glomerular capillary hypertension are not necessarily accompaniments, and that therapeutic interventions may affect systemic and glomerular pressures independently. Therapeutic interventions that control glomerular capillary hypertension protect against progressive renal injury, even in the presence of continued systemic hypertension. Conversely, therapy that controls systemic but not glomerular hypertension does not protect the kidney from continuing damage. Thus, control of intraglomerular hypertension is necessary if antihypertensive therapy is to be effective in preventing progression of renal injury.