Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure
Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure
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DOI：
10.1083/jcb.201908179
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发表时间：
2020-04
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通讯作者：
Lauren Penfield;Raakhee Shankar;E. Szentgyörgyi;A. Laffitte;M. Mauro;A. Audhya;T. Müller-Reichert;Shirin Bahmanyar
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作者：
Lauren Penfield;Raakhee Shankar;E. Szentgyörgyi;A. Laffitte;M. Mauro;A. Audhya;T. Müller-Reichert;Shirin Bahmanyar
核渗透屏障依赖于核包膜孔的闭合。Penfield等人表明，cnep -1 -脂素途径限制了内质网膜的产生，内质网膜进入并关闭核膜孔。在多余的膜产生时，核膜适配器对ESCRT-III的重塑有助于核关闭。
The nuclear permeability barrier depends on closure of nuclear envelope holes. Penfield et al. show that the CNEP-1–lipin pathway limits production of ER membranes that feed into and close nuclear envelope holes. Upon excess membrane production, remodeling by nuclear envelope adaptors to ESCRT-III contributes to nuclear closure.