Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment
Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment
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DOI：
10.1093/schbul/sbw085
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发表时间：
2017-05-01
影响因子：
6.6
通讯作者：
Andreassen, Ole A.
中科院分区：
文献类型：
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作者：
Le Hellard, Stephanie;Wang, Yunpeng;Andreassen, Ole A.
有证据表明认知能力和精神分裂症（SCZ）之间存在遗传重叠，全基因组关联研究（GWAS）表明，SCZ和一般认知能力都有很强的多基因成分，其中有许多单核苷酸多态性（SNP），每个影响都很小。在这里，我们调查了SCZ和教育程度之间的共享遗传结构，这被认为是认知能力的“代理表型”，但也可能反映其他特征。我们应用条件错误发现率（condFDR）方法，以GWAS SCZ（n = 82 315），大学完成（“大学”，n = 95 427），和多年的教育（“教育年”，n = 101 069）。与大学或EduYears相关的变异显示与SCZ相关的富集，表明多基因重叠。SCZ中的复制率增加证实了这一点。通过应用condFDR阈值
There is evidence for genetic overlap between cognitive abilities and schizophrenia (SCZ), and genome-wide association studies (GWAS) demonstrate that both SCZ and general cognitive abilities have a strong polygenic component with many single-nucleotide polymorphisms (SNPs) each with a small effect. Here we investigated the shared genetic architecture between SCZ and educational attainment, which is regarded as a "proxy phenotype" for cognitive abilities, but may also reflect other traits. We applied a conditional false discovery rate (condFDR) method to GWAS of SCZ (n = 82 315), college completion ("College," n = 95 427), and years of education ("EduYears," n = 101 069). Variants associated with College or EduYears showed enrichment of association with SCZ, demonstrating polygenic overlap. This was confirmed by an increased replication rate in SCZ. By applying a condFDR threshold