Aging and oxidative stress in progressive supranuclear palsy
Aging and oxidative stress in progressive supranuclear palsy
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DOI：
10.1111/j.1468-1331.2006.01139.x
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发表时间：
2006-01-01
影响因子：
5.1
通讯作者：
Kobayashi, S
中科院分区：
文献类型：
--
作者：
Aoyama, K;Matsubara, K;Kobayashi, S
进行性核上性麻痹（PSP）是一种神经退行性疾病，可能由氧化应激引起。然而，与年龄相关的内源性抗氧化系统的变化还没有得到很好的理解。为了更好地理解这一点，我们测量铜/锌-超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPx），4-羟基壬烯醛（HNE）结合GPx在PSP患者的脑脊液酶联免疫吸附试验。PSP组Cu/Zn-SOD活性较对照组明显升高。PSP组Cu/Zn-SOD、GPx水平与年龄呈正相关。PSP组GPx以HNE结合形式存在，占GPx总量的2/3，且与HNE结合形式呈正相关。总之，PSP患者的内源性抗氧化系统似乎随着年龄的增长而被激活，然而，由于与HNE结合，它可能无法有效地发挥作用。
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder, which may possibly be induced by oxidative stress. However, the age-related alteration of the endogenous antioxidant system is not well understood. To better understand this, we measured Cu/Zn-superoxide dismutase (SOD), glutathione peroxidase (GPx), and 4-hydroxynonenal (HNE)-conjugated GPx in cerebrospinal fluid of PSP patients by enzyme linked immunosorbent assay. A significant increase in the Cu/Zn-SOD level was detected in PSP group compared with controls. The levels of Cu/Zn-SOD and GPx in PSP group showed positive correlations with age. Two-thirds of total GPx was present as the HNE-conjugated form with positive correlation in PSP group. In conclusion, the endogenous antioxidant system of PSP patients appears to be activated with aging, however, it might be unable to function effectively because of conjugation with HNE.