Age-related macular degeneration and the incidence of cardiovascular disease: a systematic review and meta-analysis.
Age-related macular degeneration and the incidence of cardiovascular disease: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0089600
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Schaumberg DA
中科院分区：
文献类型：
--
作者：
Wu J;Uchino M;Sastry SM;Schaumberg DA
研究表明，年龄相关性黄斑变性（AMD）和心血管疾病（CVD）之间存在一些共同的致病机制。然而，关于 AMD 是否可以预测未来 CVD 风险，之前的流行病学研究结果并不一致。系统回顾基于人群的队列研究，探讨 AMD 与总 CVD 和 CVD 亚型、冠心病 (CHD) 和中风风险之间的关联。对 PubMed 和 EMBASE 数据库以及截至 2012 年 12 月 20 日的关键检索文章的参考文献列表进行系统检索，无语言限制。两名评审员独立提取有关 AMD 基线状况、CVD 风险评估以及用于评估 AMD 和 CVD 的方法的数据。我们酌情使用随机或固定效应模型来汇总相对风险。这项荟萃分析纳入了 13 项队列研究（8 项前瞻性研究和 5 项回顾性研究），共有 1,593,390 名参与者，涉及 155,500 起 CVD 事件（92,039 起中风和 62,737 起先心病）。在所有研究中，早期 AMD 与总 CVD 风险增加 15%（95% CI，1.08-1.22）相关。晚期 AMD 的相对风险相似，但不显着（RR，1.17；95% CI，0.98-1.40）。在仅限于前瞻性研究子集的分析中，与早期 AMD 相关的风险没有明显变化；然而，晚期 AMD 患者的 CVD 风险显着增加 66%（95% CI，1.31-2.10）。尽管所有队列研究的结果表明，早期和晚期 AMD 都预示着未来 CVD 风险的小幅增加，但仅限于前瞻性研究的亚组分析表明，晚期 AMD 患者的 CVD 风险显着增加。使用医疗保健数据库的回顾性研究可能具有固有的方法学局限性，从而掩盖了这种关联。需要更多的前瞻性研究来进一步阐明 AMD 与特定 CVD 结果之间的关联。
Research has indicated some shared pathogenic mechanisms between age-related macular degeneration (AMD) and cardiovascular disease (CVD). However, results from prior epidemiologic studies have been inconsistent as to whether AMD is predictive of future CVD risk. To systematically review population-based cohort studies of the association between AMD and risk of total CVD and CVD subtypes, coronary heart disease (CHD) and stroke. A systematic search of the PubMed and EMBASE databases and reference lists of key retrieved articles up to December 20, 2012 without language restriction. Two reviewers independently extracted data on baseline AMD status, risk estimates of CVD and methods used to assess AMD and CVD. We pooled relative risks using random or fixed effects models as appropriate. Thirteen cohort studies (8 prospective and 5 retrospective studies) with a total of 1,593,390 participants with 155,500 CVD events (92,039 stroke and 62,737 CHD) were included in this meta-analysis. Among all studies, early AMD was associated with a 15% (95% CI, 1.08–1.22) increased risk of total CVD. The relative risk was similar but not significant for late AMD (RR, 1.17; 95% CI, 0.98–1.40). In analyses restricted to the subset of prospective studies, the risk associated with early AMD did not appreciably change; however, there was a marked 66% (95% CI, 1.31–2.10) increased risk of CVD among those with late AMD. Whereas the results from all cohort studies suggest that both early and late AMD are predictive of a small increase in risk of future CVD, subgroup analyses limited to prospective studies demonstrate a markedly increased risk of CVD among people with late AMD. Retrospective studies using healthcare databases may have inherent methodological limitations that obscure such association. Additional prospective studies are needed to further elucidate the associations between AMD and specific CVD outcomes.
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影响因子：
8.3
作者：
Ikram MK;Mitchell P;Klein R;Sharrett AR;Couper DJ;Wong TY
通讯作者：
Wong TY
影响因子：
--
作者：
Nguyen-Khoa, Bao-Anh;Goehring, Earl L., Jr.;Jones, Judith K.
通讯作者：
Jones, Judith K.
DOI：
10.1073/pnas.0501536102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Hageman, GS;Anderson, DH;Allikmets, R
通讯作者：
Allikmets, R
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
13.7
作者：
Hogg, Ruth E.;Woodside, Jayne V.;Chakravarthy, Usha
通讯作者：
Chakravarthy, Usha