Murine B7-H3 is a negative regulator of T cells
Murine B7-H3 is a negative regulator of T cells
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DOI：
10.4049/jimmunol.173.4.2500
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发表时间：
2004-08-15
影响因子：
4.4
通讯作者：
Dong, C
中科院分区：
文献类型：
--
作者：
Prasad, DVR;Nguyen, T;Dong, C
T细胞活化由先天免疫系统通过正性和负性共刺激分子调节。B7-H3是一种新的B7样分子，在活化的T细胞上具有假定的受体。人B7-H3最初被描述为阳性共刺激分子，最有效地诱导IFN-γ产生和细胞免疫。在这项研究中，我们研究了小鼠B7-H3的表达和功能。B7-H3主要在专职APC上表达;其在树突状细胞上的表达似乎被LPS上调。与人B7-H3相反，我们发现小鼠B7-H3蛋白抑制T细胞活化和效应细胞因子产生。抗B7-H3单克隆抗体在体外可促进T细胞增殖，在体内可导致实验性自体免疫性脑脊髓炎加重。因此，小鼠B7-H3充当T细胞活化和功能的负调节剂。
T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on activated T cells. Human B7-H3 was first described as a positive costimulator, most potently inducing IFN-gamma production and cellular immunity. In this study we examined the expression and function of mouse B7-H3. B7-H3 is mostly expressed on professional APCs; its expression on dendritic cells appears to be up-regulated by LPS. In contrast to human B7-H3, we found that mouse B7-H3 protein inhibited T cell activation and effector cytokine production. An antagonistic mAb to B7-H3 enhanced T cell proliferation in vitro and led to exacerbated experimental autoinumme encephalomyelitis in vivo. Therefore, mouse B7-H3 serves as a negative regulator of T cell activation and function.