Preliminary research on a novel bioactive silicon doped calcium phosphate coating on AZ31 magnesium alloy via electrodeposition
Preliminary research on a novel bioactive silicon doped calcium phosphate coating on AZ31 magnesium alloy via electrodeposition
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DOI：
10.1016/j.msec.2013.11.041
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发表时间：
2014-03-01
影响因子：
7.9
通讯作者：
Yang, Ke
中科院分区：
文献类型：
--
作者：
Qiu, Xun;Wan, Peng;Yang, Ke
采用脉冲电沉积法在AZ 31镁合金表面制备了硅掺杂磷酸钙涂层。观察到一种新型的双层结构，多孔层状和外部块状磷灰石层。采用体外模拟体液浸泡试验，浸泡时间为28天。Si掺杂的Ca-P涂层失重降解速率较慢，这也与电化学实验结果一致，表明涂层的耐腐蚀性增强。浸泡后涂层表面进一步形成类磷灰石层，证明涂层具有更好的完整性和生物矿化性能。对MG 63成骨样细胞的活力、增殖和分化进行生物学表征。涂层显示出良好的细胞生长和增强的细胞增殖。实验结果表明，硅掺杂磷酸钙材料作为镁合金植入物的涂层材料，可以有效控制镁合金植入物的降解速率，提高镁合金植入物的生物活性，促进骨组织的快速修复。(C)2013爱思唯尔有限公司版权所有。
A silicon doped calcium phosphate coating was obtained successfully on AZ31 alloy substrate via pulse electrodeposition. A novel dual-layer structure was observed with a porous lamellar-like and outer block-like apatite layer. In vitro immersion tests were adopted in simulated body fluid within 28 days of immersion. Slow degradation rate obtained from weight loss was observed for the Si-doped Ca-P coating, which was also consistent with the results of electrochemical experiments showing an enhanced corrosion resistance for the coating. Further formation of an apatite-like layer on the surface after immersion proved better integrity and biomineralization performance of the coating. Biological characterization was carried out for viability, proliferation and differentiation of MG63 osteoblast-like cells. The coating showed a good cell growth and an enhanced cell proliferation. Moreover, an increased activity of osteogenic marker ALP was found. All the results demonstrated that the Si-doped calcium phosphate was perspective to be used as a coating for magnesium alloy implants to control the degradation rate and enhance the bioactivity, which would facilitate the rapidity of bone tissue repair. (C) 2013 Elsevier B.V. All rights reserved.