Dose-response characteristics of a ferrous-sulphate-doped gelatin system for determining radiation absorbed dose distributions by magnetic resonance imaging (Fe MRI).

Dose-response characteristics of a ferrous-sulphate-doped gelatin system for determining radiation absorbed dose distributions by magnetic resonance imaging (Fe MRI).
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硫酸亚铁掺杂明胶系统的剂量响应特性,用于通过磁共振成像 (Fe MRI) 确定辐射吸收剂量分布。

DOI:
10.1088/0031-9155/36/8/007
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发表时间:
1991
影响因子:
3.5
通讯作者:
Boyer,AL
Boyer,AL
中科院分区:
工程技术2区
文献类型:
--
作者:
Hazle,JD;Hefner,L;Nyerick,CE;Wilson,L;Boyer,AL

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研究了固定于明胶基质中硫酸亚铁掺杂化学剂量计系统(Fe MRI)的核磁共振(NMR)纵向弛豫率r1剂量响应特性。将含有不同浓度feso4剂量计的样品照射到0-150 Gy的吸收剂量。在磁场强度为1.5 T (1 H Lamor频率为63.8 MHz)下对样品进行成像,以确定r1弛豫速率。对于所研究的所有feso4浓度(0.1-2.0 mM),系统的响应发现在50 Gy剂量下近似线性。浓度在0.1 ~ 0.5 mM范围内的变化对剂量-响应曲线的斜率和截距均有影响。在0.5 ~ 2.0 mM剂量范围内,剂量-响应曲线斜率保持在0.0423 s-1 Gy-1左右。然而,正如预期的那样,由于额外的顺磁性离子,曲线的截距在该区域继续增加。在22厘米视场范围内进行测量的吸收剂量估计的再现性在20-50戈瑞范围内为5%(平均不确定度为0.81戈瑞),在5-10戈瑞剂量范围内下降到约10%。
The nuclear magnetic resonance (NMR) longitudinal relaxation rate R 1 dose-response characteristics of a ferrous-sulphate-doped chemical dosimeter system (Fe MRI) immobilized in a gelatin matrix were explored. Samples containing various concentrations of the FeSO 4 dosimeter were irradiated to absorbed doses of 0-150 Gy. R 1 relaxation rates were determined by imaging the samples at a field strength of 1.5 T (1 H Lamor frequency of 63.8 MHz). The response of the system was found to be approximately linear up to doses of 50 Gy for all FeSO 4 concentrations studied (0.1-2.0 mM). Changing concentrations in the range of 0.1-0.5 mM affected both the slope and intercept of the dose-response curve. For concentrations of 0.5-2.0 mM, the slope of the dose-response curves remained constant at approximately 0.0423 s-1 Gy-1 in the dose range of 0-50 Gy. However, the intercept of the curve continued to increase in that region, as expected, because of the additional paramagnetic ions. The reproducibility of the absorbed dose estimates for measurements made over a 22 cm field of view was found to be 5% in the range of 20-50 Gy (an uncertainty of 0.81 Gy on average), decreasing to approximately 10% in the dose range of 5-10 Gy.
介绍性回顾:使用核磁共振的辐射剂量测定:介绍性回顾
DOI: --
发表时间: 1990
期刊:
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期刊: Medical Physics (Lancaster)
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