Angiotensin II-noradrenergic interactions in renovascular hypertensive rats.
Angiotensin II-noradrenergic interactions in renovascular hypertensive rats.
复制标题
肾血管性高血压大鼠中血管紧张素 II-去甲肾上腺素能相互作用。
DOI：
10.1172/jci113092
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Jackson,EK
中科院分区：
文献类型：
--
作者：
Zimmerman,JB;Robertson,D;Jackson,EK
本研究验证了内源性血管紧张素II （AII）与去甲肾上腺素能神经效应连接的相互作用在肾素依赖性高血压中很重要的假设。在原位血流灌注的大鼠肠系膜中，外源性AII增强了肠系膜血管对动脉周围（交感）神经刺激（PNS）的反应，而不是血管对外源性去甲肾上腺素（NE）的反应。在2肾-1夹（2K-1C）肾血管性高血压大鼠中，肠系膜血管对PNS和NE的反应大于假手术大鼠，并且肾血管性高血压在增强PNS反应方面模拟了外源性AII的作用，而不是对NE的反应。在2K-1C大鼠中，1-Sar-8-Ile-AII明显抑制血管对PNS的反应，而不影响对NE的反应，但在假手术大鼠中没有。最后，1-Sar-8-Ile-AII减轻了交感神经刺激诱导的2K-1C大鼠NE的神经元溢出，但在假手术大鼠中没有。这些数据表明，肾血管性高血压增强去甲肾上腺素能神经传递，而这种增强部分是由aii诱导的NE释放促进介导的。
This study tested the hypothesis that interactions of endogenous angiotensin II (AII) with the noradrenergic neuroeffector junction are important in renin-dependent hypertension. In the in situ blood-perfused rat mesentery, in normal rats exogenous AII potentiated mesenteric vascular responses to periarterial (sympathetic) nerve stimulation (PNS) more than vascular responses to exogenous norepinephrine (NE). In 2-kidney-1-clip (2K-1C) rats with renovascular hypertension mesenteric vascular responses to PNS and NE were greater than in sham-operated rats, and renovascular hypertension mimicked the effects of exogenous AII with respect to enhancing responses to PNS more than responses to NE. In 2K-1C rats, but not in sham-operated rats, 1-Sar-8-Ile-AII markedly suppressed vascular responses to PNS, without influencing responses to NE. Finally, 1-Sar-8-Ile-AII attenuated sympathetic nerve stimulation-induced neuronal spillover of NE in 2K-1C rats, but not in sham-operated rats. These data indicate that renovascular hypertension enhances noradrenergic neurotransmission, and that this enhancement is mediated in part by AII-induced facilitation of NE release.