A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response
A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response
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DOI：
10.1167/tvst.7.6.27
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发表时间：
2018-12-01
影响因子：
3
通讯作者：
Crowston, Jonathan G.
中科院分区：
文献类型：
--
作者：
Tang, Jessica;Hui, Flora;Crowston, Jonathan G.
目的：为了比较RETeval传感器条和Dawson-Trick-Litzkow（DTL）电极记录明视负反应（PhNR）使用便携式视网膜电图（ERG）设备在眼睛和没有glaucoma.Methods：26个控制和31青光眼或青光眼可疑参与者被招募。使用LKC RETeval设备，以随机顺序用传感器条和DTL电极记录明视觉ERG。刺激由蓝色背景（明视10 cd/m（2））上的短暂红色闪光（1.7 cd.s/m（2））组成。测量从基线到谷值的PhNR振幅，并表示为与b波振幅的比值。（平均6个标准差[SD]，4.8 +/- 2.1 vs. 12.7 +/- 4.8 mu V，P < 0.0001），信噪比较低（SNR; 5.5 +/- 2.1 vs. 8.1 +/- 3.9，P < 0.0001），与DTL电极相比，PhNR/b波比值有更大的趋势。PhNR振幅、隐式时间和PhNR/b波比值与视野平均光敏感度相关，尽管这对传感器条记录的PhNR振幅没有显著意义。电极表现出类似的会话间的重复性与重复性的系数为+/- 27%和+/- 28%的DTL和传感器strip，respectively.Conclusions：传感器条电极是一个可行的替代记录可重复的PhNR，特别是当值被归一化的b波。然而，DTL电极应考虑在衰减的PhNR的情况下，或在噪声水平升高，由于其更好的信号噪声quality.Translational相关性：传感器带电极可以简化PhNR记录在临床上，潜在地消除了需要一个有经验的操作员。
Purpose: To compare the RETeval sensor strip and Dawson-Trick-Litzkow (DTL) electrodes for recording the photopic negative response (PhNR) using a portable electroretinogram (ERG) device in eyes with and without glaucoma.Methods: Twenty-six control and 31 glaucoma or glaucoma-suspect participants were recruited. Photopic ERGs were recorded with sensor strip and DTL electrodes in random order using the LKC RETeval device. Stimuli consisted of brief, red flashes (1.7 cd.s/m(2)) on a blue background (photopic 10 cd/m(2)). The PhNR amplitude was measured from baseline to trough and also expressed as a ratio over the b-wave amplitude.Results: The sensor strip-recorded PhNR amplitude was significantly attenuated (mean 6 standard deviation [SD], 4.8 +/- 2.1 vs. 12.7 +/- 4.8 mu V, P < 0.0001), with lower signal-to-noise ratio (SNR; 5.5 +/- 2.1 vs. 8.1 +/- 3.9, P < 0.0001), and a trend toward a larger PhNR/b-wave ratio compared with DTL electrodes. The PhNR amplitude, implicit time and PhNR/b-wave ratio correlated with visual field mean light sensitivity, although this fell short of significance for the sensor strip recorded PhNR amplitude. The electrodes demonstrated similar intersession repeatability with a coefficient of repeatability of +/- 27% and +/- 28% for the DTL and sensor strip, respectively.Conclusions: Sensor strip electrodes are a viable alternative for recording reproducible PhNRs, especially when values are normalized to the b-wave. However, DTL electrodes should be considered in cases of attenuated PhNR, or in elevated noise levels, due to its better signal-to-noise quality.Translational Relevance: Sensor strip electrodes can simplify PhNR recordings in the clinic, potentially eliminating the need for an experienced operator.