BEHAVIORAL AND ANATOMICAL STUDIES OF THE POSTERIOR PARIETAL CORTEX IN THE RAT
BEHAVIORAL AND ANATOMICAL STUDIES OF THE POSTERIOR PARIETAL CORTEX IN THE RAT
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大鼠后顶叶皮层的行为和解剖学研究
DOI：
10.1016/0166-4328(87)90050-7
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发表时间：
1987-02-01
影响因子：
2.7
通讯作者：
WALKEY, J
中科院分区：
文献类型：
--
作者：
KOLB, B;WALKEY, J
灵长类动物有一个后皮层区域，其特征是往返于额叶联合皮层的多模态感觉投射，以及该区域损伤导致的明显行为综合征。通过两个系列的实验（一个是解剖学的，另一个是行为学的）对大鼠的后联合皮层进行了检查，看看是否可以找到类似的区域。通过将逆行示踪剂 True blue 放入额叶或后皮层，检查了大鼠克里格 7 区的解剖连接，并在各种任务中研究了去除该皮层的大鼠的行为。该区域似乎是一个多模式感觉关联区域。它接收来自纹状体（区域 17）、纹状体外（区域 18a 和 18b）和体感皮层（区域 3）的投射。它还与后扣带皮层和内侧额叶皮层中的两个额叶关联区（即前扣带皮层和额叶眼区）相互连接。 病变在触觉辨别和走窄梁任务上产生缺陷，这两项任务要求动物准确导航到空间中的一个点，以及一项需要关联两个空间上不连续线索的任务。这些动物在寻找提示或打开拼图闩锁方面没有受到损害。总体而言，结果表明大鼠具有可能类似于灵长类动物的后顶叶皮层的感觉关联区。
Primates have an area of posterior cortex characterized by multimodal sensory projections to and from the frontal association cortex and a clear behavioural syndrome resulting from lesions to this zone. The posterior association cortex of the rat was examined in two series of experiments, one anatomical and one behavioural, to see if an analogous region could be found. The anatomical connections of Krieg''s area 7 in the rat were examined by placing the retrograde tracer, True blue, into the frontal or posterior cortex, and the behaviour of rats with this cortex removed was studied on a variety of tasks. This area appears to be a multimodal sensory association region. It receives projections from striate (area 17), extrastriate (areas 18a and 18b), and somatosensory cortex (area 3). It is also reciprocally connected with the posterior cingulate cortex and two frontal association zones in the medial frontal cortex, namely the anterior cingulate cortex and the frontal eye fields. Lesions produced deficits on tasks of tactile discrimination, and walking a narrow beam, two tasks requiring animals to navigate accurately to a point in space, and a task requiring the association of two spatially discontiguous cues. The animals were not impaired at navigating to a cue or in opening puzzle latches. Overall, the results show that the rat has a sensory association zone that may be analogous to the posterior parietal cortex of primates.