THEORY OF THE INFLUENCE OF END CONDITIONS ON SELF-CONTACT IN DNA LOOPS
THEORY OF THE INFLUENCE OF END CONDITIONS ON SELF-CONTACT IN DNA LOOPS
复制标题
终止条件对 DNA 环自接触的影响理论
DOI：
10.1063/1.470021
复制
发表时间：
1995
影响因子：
4.4
通讯作者：
D. Swigon
中科院分区：
文献类型：
--
作者：
B. D. Coleman;I. Tobias;D. Swigon
明确的解决方案的基尔霍夫的弹性棒理论的方程推导出属性的三级结构的一个环段的DNA是受几何约束强加在其端点的结合蛋白质。在适当的情况下，这种边界数据的微小变化会导致近平面环经历连续和可逆的转变，其可以被描述为180°旋转，使环从未交叉的结构变为单交叉的结构，其中顺序分离的碱基对被接近。表达式推导出相关的点和角度的交叉结束条件，并提出结果，便于计算在这种过渡过程中的弹性能的变化。
Explicit solutions of the equations of Kirchhoff’s theory of elastic rods are employed to derive properties of the tertiary structure of a looped segment of DNA that is subject to geometric constraints imposed at its end points by bound proteins. In appropriate circumstances small changes in such boundary data cause a nearly planar loop to undergo a continuous and reversible transition that can be described as a 180° rotation taking the loop from an uncrossed to a singly crossed structure in which sequentially separated base pairs are brought into proximity. Expressions are derived relating points and angles of crossing to end conditions, and results are presented that facilitate the calculation of changes in elastic energy during such transitions.