Bypassing the midgut results in development of Plasmodium berghei oocysts in a refractory strain of Anopheles gambiae (Diptera: Culicidae).
Bypassing the midgut results in development of Plasmodium berghei oocysts in a refractory strain of Anopheles gambiae (Diptera: Culicidae).
复制标题
绕过中肠会导致冈比亚按蚊（双翅目：蚊科）难治菌株中伯氏疟原虫卵囊的发育。
DOI：
10.1093/jmedent/42.4.712
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发表时间：
2005
影响因子：
2.1
通讯作者：
Shi,Lei
中科院分区：
文献类型：
--
作者：
Paskewitz,SusanM;Shi,Lei
The L35 strain ofAnopheles gambiaeGiles was genetically selected for its ability to melanize and kill malaria parasites. A wide range ofPlasmodiumspecies are subject to this response when orally ingested, including the rodent malaria,P. berghei. However, when we directly injectedP. bergheiinto the hemocoel, we found that parasites developed normally to the oocyst stage. This work suggests that the parasite melanization response depends on the interaction of the ookinetes and the midgut. This result is surprising because it contrasts with a genetically validated model system, where injection of CM-Sephadex beads directly into the hemocoel results in bead melanization.
