Positioning of longitudinal nerves in C-elegans by nidogen
Positioning of longitudinal nerves in C-elegans by nidogen
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DOI：
10.1126/science.288.5463.150
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发表时间：
2000-04-07
期刊：
影响因子：
56.9
通讯作者：
Wadsworth, WG
中科院分区：
文献类型：
--
作者：
Kim, S;Wadsworth, WG
基底膜可以帮助确定轴突迁移的路径。虽然Nidogen(Entactin)蛋白家族的成员是基底膜的结构成分，但我们发现线虫线虫的基底膜组装不需要Nidogen。Nidogen定位于体壁基底膜，并需要引导纵神经背腹和中线轴突。通过研究单个轴突在体内的迁移，我们证明了轴突从周向迁移到纵向迁移需要Nidgen。因此，特殊的基底膜可能会调节神经位置。
Basement membranes can help determine pathways of migrating axons. Although members of the nidogen (entactin) protein family are structural components of basement membranes, we find that nidogen is not required for basement membrane assembly in the nematode Caenorhabditis elegans. Nidogen is Localized to body wall basement membranes and is required to direct longitudinal nerves dorsoventrally and to direct axons at the midlines. By examining migration of a single axon in vivo, we show that nidogen is required for the axon to switch from circumferential to Longitudinal migration. Specialized basement membranes may thus regulate nerve position.