The Activating Killer Cell Immunoglobulin-Like Receptors as Important Determinants of Acute Graft-Versus Host Disease in Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
The Activating Killer Cell Immunoglobulin-Like Receptors as Important Determinants of Acute Graft-Versus Host Disease in Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
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激活杀伤细胞免疫球蛋白样受体是急性骨髓性白血病造血干细胞移植中急性移植物抗宿主病的重要决定因素
DOI：
10.1097/01.tp.0000285918.72930.35
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发表时间：
2007
期刊：
影响因子：
6.2
通讯作者：
Chun‐Choo Kim
中科院分区：
文献类型：
--
作者：
Hee‐Je Kim;Young Choi;W. Min;Tai;B. Cho;Sung;K. Eom;Seok Lee;C. Min;Seok;Dong;Jong;Chun‐Choo Kim
背景资料。我们根据抑制或激活KIR的基因类型，研究了急性髓系白血病干细胞受者及其人类白细胞抗原相合的同胞供者中KIR基因对造血干细胞移植后急性移植物抗宿主病(GVHD)的影响。方法：研究方法。我们研究了连续的53对供受者，以确定KIR基因型及其双向KIR相互作用的影响。结果。捐献者中所有激活的KIR基因都是决定结果的重要因素，其方式与所研究的每个基因不同。2DS2基因和2DS4*003等位基因与急性移植物抗宿主病密切相关。2DS1基因与更好的长期存活有关，即使只存在于捐赠者而不是接受者。2ds3-2ds5双基因更常与移植相关的各种并发症有关。结论。综上所述，这些因素可能有助于预测移植结果，并有助于我们理解免疫遗传特异性。
Background. We investigated the influence of killer cell immunoglobulin-like receptor (KIR) genes, based on the genotypes of inhibitory or activating KIR, in stem cell recipients with acute myelogenous leukemia and their human leukocyte antigen-matched sibling donors on acute graft-versus host disease (GVHD) after hematopoietic stem cell transplantation. Methods. We studied 53 consecutive donor–recipient pairs to determine the impact of KIR genotypes and their bidirectional KIR interactions. Results. All activating KIR genes in donors were important factors for determining outcome in a manner distinctive for each gene studied. Specifically, the 2DS2 gene and the 2DS4*003 allele were closely correlated with acute GVHD. The 2DS1 gene was associated with a better long-term survival, even if present only in the donor and not the recipient. The 2DS3–2DS5 dual genes were more often involved in a variety of transplant-related complications. Conclusions. In conclusion, these factors may help predict transplant outcomes and aid in our understanding of immunogenetic specificity.
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影响因子：
1.3
作者：
M. Yawata;N. Yawata;L. Abi-Rached;P. Parham
通讯作者：
M. Yawata;N. Yawata;L. Abi-Rached;P. Parham
影响因子：
20.3
作者：
Cooley, S;McCullar, V;Miller, JS
通讯作者：
Miller, JS
影响因子：
32.4
作者：
Uhrberg, M;Valiante, NM;Parham, P
通讯作者：
Parham, P
影响因子：
20.3
作者：
Sconocchia, G;Lau, M;Barrett, AJ
通讯作者：
Barrett, AJ