Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy
Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy
复制标题
使用功能性近红外光谱评估托莫西汀对注意缺陷多动障碍儿童在奇怪范式中注意力网络的神经药理学作用
DOI：
10.1117/1.nph.1.2.025007
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发表时间：
2014
期刊：
影响因子：
5.3
通讯作者：
Eiju Watanabe
中科院分区：
文献类型：
--
作者：
Masako Nagashima;Yukifumi Monden;Ippeita Dan;Haruka Dan;Tsutomu Mizutani;Daisuke Tsuzuki;Yasushi Kyutoku;Yuji Gunji;Daisuke Hirano;Takamichi Taniguchi;Hideo Shimoizumi;Mariko Y. Momoi;Takanori Yamagata;Eiju Watanabe
本研究旨在使用功能性近红外光谱（fNIRS）探索托莫西汀对注意缺陷多动障碍（ADHD）学龄儿童注意控制影响的神经底物，该方法比传统神经影像学方法更容易应用于ADHD幼儿。我们采用随机、双盲、安慰剂对照、交叉设计，使用fNIRS监测了15名ADHD儿童（6至14岁）在托莫西汀或安慰剂给药前和给药后1.5小时执行古怪任务时的氧合血红蛋白信号变化。还监测了15名年龄、性别和智力匹配的未接受托莫西汀给药的正常对照。在对照组中，古怪的任务招募了右前额叶和顶叶下皮层。ADHD儿童托莫西汀给药后，右前额叶和顶叶激活恢复正常。这与我们之前使用类似方案的研究相反，该研究显示哌甲酯仅诱导右前额功能正常化。fNIRS允许检测注意力网络中两种物质的不同神经药理学特征：托莫西汀上调去甲肾上腺素能系统的神经药理学作用（反映在右前额和下顶叶激活中）和哌甲酯上调多巴胺系统的神经药理学作用（反映在前额皮质激活中）。
The current study aimed to explore the neural substrate for atomoxetine effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 15 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after atomoxetine or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices. The right prefrontal and parietal activation was normalized after atomoxetine administration in ADHD children. This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.