Clinical and Molecular Epidemiology of Human Rhinovirus C in Children and Adults in Hong Kong Reveals a Possible Distinct Human Rhinovirus C Subgroup
Clinical and Molecular Epidemiology of Human Rhinovirus C in Children and Adults in Hong Kong Reveals a Possible Distinct Human Rhinovirus C Subgroup
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DOI：
10.1086/605697
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发表时间：
2009-10-01
影响因子：
6.4
通讯作者：
Yuen, Kwok-Yung
中科院分区：
文献类型：
--
作者：
Lau, Susanna K. P.;Yip, Cyril C. Y.;Yuen, Kwok-Yung
背景。最近发现了一种新的人类鼻病毒 (HRV) 物种 HRV-C，但与 HRV-A 和 HRV-B 相比，人们对其临床特征和流行病学仍知之甚少，尤其是在成人中。一年内从住院儿童和成人中采集的 1200 份鼻咽吸出物样本经过逆转录聚合酶链反应检测 HRV。对3种HRV的临床和分子流行病学进行了分析。结果。在 600 份儿童鼻咽抽吸物样本中检测到 178 份（29.7%）HRV，在 600 份成人鼻咽抽吸物样本中检测到 42 份（7%）HRV。 HRV-A 最为常见 (n = 111)，其次是 HRV-C (n = 91) 和 HRV-B (n = 18)。虽然上呼吸道感染是儿童中最常见的症状，但 13 名 HRV-C 感染成人中，有 8 名 (62%) 患有肺炎，而 22 名 HRV-A 感染成人中，有 6 名 (27%) (P < .05)。 HRV-C (37%) 和 HRV-A (20%) 感染者的喘息发作也比 HRV-B (0%) 感染者更常见 (P < .05)。临床和分子数据分析表明 HRV-C 是社区和机构化疫情爆发的常见原因。全年传播着多种 HRV-C 基因型，其中观察到了潜在的独特菌株亚群。结论。 HRV-C 与成人肺炎和需要住院治疗的呼吸道感染爆发有关。确定了一个潜在的新 HRV-C 亚组。
Background. A novel human rhinovirus (HRV) species, HRV-C, was recently discovered, but its clinical features and epidemiology, compared with HRV-A and HRV-B, remains poorly understood, especially in adults.Methods. One thousand two hundred nasopharyngeal aspirate samples obtained from hospitalized children and adults during a 1-year period were subject to reverse-transcriptase polymerase chain reaction to detect HRV. The clinical and molecular epidemiology of the 3 HRV species was analyzed.Results. HRVs were detected in 178 (29.7%) of 600 nasopharyngeal aspirate samples from children and 42 (7%) of 600 nasopharyngeal aspirate samples from adults. HRV-A was most prevalent (n = 111), followed by HRV-C (n = 91) and HRV-B (n = 18). Although upper respiratory tract infection was the most common presentation in children, 8 (62%) of the 13 adults with HRV-C infection had pneumonia, compared with 6 (27%) of the 22 adults with HRV-A infection (P < .05). Wheezing episodes were also more common among individuals with HRV-C (37%) and HRV-A (20%) infection than among those with HRV-B (0%) infection (P < .05). Clinical and molecular data analysis revealed HRV- C as a frequent cause of community and institutionalized outbreaks. A diverse set of HRV-C genotypes was circulating throughout the year, among which a potential distinct subgroup of strains was observed.Conclusion. HRV-C is associated with pneumonia in adults and outbreaks of respiratory infections requiring hospitalization. A potential novel HRV-C subgroup was identified.