Reactive oxygen species and peroxisomes: Struggling for balance
Reactive oxygen species and peroxisomes: Struggling for balance
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DOI：
10.1002/biof.48
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发表时间：
2009-07-01
期刊：
影响因子：
6
通讯作者：
Schrader, Michael
中科院分区：
文献类型：
--
作者：
Bonekamp, Nina A.;Voelkl, Alfred;Schrader, Michael
活性氧是细胞内一种多功能的生物因子。已知它们参与常规细胞功能，例如，作为信号介质，但在氧化应激条件下的过量产生导致有害的细胞效应、细胞死亡和多种病理状况。过氧化物酶体功能长期以来一直与氧代谢有关，这是由于过氧化物酶体中高浓度的H2O2生成氧化酶及其一组抗氧化酶，特别是过氧化氢酶。尽管如此，线粒体仍然被置于ROS代谢和氧化应激的中心。这篇综述讨论了关于ROS和过氧化物酶体之间关系的新发现，因为它们揭示了ROS代谢和氧化损伤的动态旋转中的关键角色。将给出ROS生成酶及其抗氧化剂对应物的概述，举例说明相对系统之间的精确微调。各种条件下，其中产生和清除过氧化物酶体中的ROS之间的平衡被扰乱，例如，外源性操纵，老化和过氧化物酶体疾病，得到解决。此外，过氧化物酶体衍生的氧化应激及其对线粒体（反之亦然）的影响进行了讨论，突出了两个细胞器的密切相互关系。
Reactive oxygen species (ROS) can surely be considered as multifunctional biofactors within the cell. They are known to participate in regular cell functions, for example, as signal mediators, but overproduction under oxidative stress conditions leads to deleterious cellular effects, cell death and diverse pathological conditions. Peroxisomal function has long been linked to oxygen metabolism due to the high concentration of H2O2-generating oxidases in peroxisomes and their set of antioxidant enzymes, especially catalase. Still, mitochondria have been very much placed in the Centre of ROS metabolism and oxidative stress. This review discusses novel findings concerning the relationship between ROS and peroxisomes, as they revealed to be a key player in the dynamic spin of ROS metabolism and oxidative injury. An overview of ROS generating enzymes as well as their antioxidant counterparts will be given, exemplifying the precise fine-tuning between the opposing systems. Various conditions in which the balance between generation and scavenging of ROS in peroxisomes is perturbed, for example, exogenous manipulation, ageing and peroxisomal disorders, are addressed. Furthermore, peroxisome-derived oxidative stress and its effect on mitochondria (and vice versa) are discussed, highlighting the close interrelationship of both organelles.