Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression
Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression
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DOI：
10.1007/s00384-010-0913-x
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发表时间：
2010-03
影响因子：
2.8
通讯作者：
S. Fujita;H. Taniguchi;T. Yao;T. Shimoda;H. Ueno;T. Hirai;M. Ohue
中科院分区：
文献类型：
--
作者：
S. Fujita;H. Taniguchi;T. Yao;T. Shimoda;H. Ueno;T. Hirai;M. Ohue
背景结直肠癌肝转移的危险因素尚不清楚。因此，我们评估了结直肠癌患者中各种临床病理因素（包括 CD10 表达、肝转移和生存）之间的关系。方法收集并评估了 4 家参与医院的 1,025 例 II 期或 III 期结直肠癌患者接受根治性手术的临床病理数据。三位病理学家在不了解临床结果的情况下检查了局灶性去分化、静脉侵犯和 CD10 表达。结果单变量分析显示病理 T (pT)、病理性 N (pN)、静脉侵犯、局灶性去分化和 CD10 表达与肝转移显着相关。多变量分析选择 pT、pN 和 CD10 表达作为肝转移的重要危险因素。单变量和多变量分析还显示 pT、pN 和 CD10 与无病生存显着相关。 CD10阴性或pT2或pT3肿瘤的pN0患者肝转移发生率为3%，CD10阳性或pT4肿瘤的pN2患者肝转移发生率为28%。结论CD10表达是结直肠癌患者肝转移的重要危险因素，且与预后相关。可以根据pT、pN和CD10表达来选择肝转移风险高的患者。
BackgroundThe risk factors for liver metastasis from colorectal cancer are still unclear. We therefore evaluated the relationships between various clinicopathological factors, including CD10 expression, liver metastasis, and survival, in patients with colorectal cancer.MethodsClinicopathological data for 1,025 patients with stage II or III colorectal cancer who underwent curative surgery in four participating hospitals were collected and evaluated. Three pathologists examined focal dedifferentiation, venous invasion, and CD10 expression without knowledge of the clinical outcome.ResultsUnivariate analysis showed that pathological T (pT), pathological N (pN), venous invasion, focal dedifferentiation, and CD10 expression were significantly associated with liver metastasis. Multivariate analysis selected pT, pN, and CD10 expression as significant risk factors for liver metastasis. pT, pN and CD10 were also shown by univariate and multivariate analyses to be significantly associated with disease-free survival. The incidence of liver metastasis was 3% in pN0 patients with CD10-negative or pT2 or pT3 tumors and 28% in pN2 patients with CD10-positive or pT4 tumors.ConclusionsCD10 expression is a significant risk factor for liver metastasis in patients with colorectal cancer and is correlated with prognosis. Patients with a high risk of liver metastasis can be selected on the basis of pT, pN, and CD10 expression.