Ultrasensitive molecular controllers for quasi-integral feedback
Ultrasensitive molecular controllers for quasi-integral feedback
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DOI：
10.1016/j.cels.2021.01.001
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发表时间：
2021-03-17
期刊：
影响因子：
9.3
通讯作者：
Franco, Elisa
中科院分区：
文献类型：
--
作者：
Samaniego, Christian Cuba;Franco, Elisa
反馈控制通过减轻可变性、未知干扰和噪声的影响，使自动化技术获得成功。虽然已知生物反馈回路减少噪声的影响并有助于形成动力学响应，但关于如何设计分子积分控制器仍存在许多问题。在这里，我们提出了一个模块化的策略来构建分子准积分反馈控制器，其中涉及以下两个设计原则。第一个原则是利用超灵敏响应，这决定了控制器的增益，并影响稳态误差。第二种是使用超灵敏响应的可调阈值，其确定系统的平衡点。我们描述了一个反应网络，命名为边缘控制器，满足这些条件，结合分子螯合和激活/失活循环。与计算模型，我们研究潜在的生物实现的边缘控制器，我们说明了不同的例子应用。
Feedback control has enabled the success of automated technologies bymitigating the effects of variability, unknown disturbances, and noise. While it is known that biological feedback loops reduce the impact of noise and help shape kinetic responses, many questions remain about how to design molecular integral controllers. Here, we propose a modular strategy to build molecular quasi-integral feedback controllers, which involves following two design principles. The first principle is to utilize an ultrasensitive response, which determines the gain of the controller and influences the steady-state error. The second is to use a tunable threshold of the ultrasensitive response, which determines the equilibrium point of the system. We describe a reaction network, named brink controller, that satisfies these conditions by combining molecular sequestration and an activation/deactivation cycle. With computational models, we examine potential biological implementations of brink controllers, and we illustrate different example applications.