Role of nitric oxide in 2-deoxy-D-glucose-induced hypothermia in rats
Role of nitric oxide in 2-deoxy-D-glucose-induced hypothermia in rats
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DOI：
10.1097/00001756-199909290-00041
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发表时间：
1999-09-29
期刊：
影响因子：
1.7
通讯作者：
Branco, LGS
中科院分区：
文献类型：
--
作者：
Carnio, EC;Almeida, MC;Branco, LGS
THE present study was designed to test the hypothesis that nitric:oxide (NO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature of awake, unrestrained rats was measured before and after the administration of 2-DG, or NG-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibitor) or both treatments together. We observed a significant reduction in body temperature after 2-DG injection. L-NAME alone caused no significant change in body temperature. When the two treatments were combined, a-reduction in the magnitude of 2-DG-induced hypothermia was observed. The neuronal NOS inhibitor 7-nitroindazole also inhibited 2-DG-induced hypothermia.:The data indicate that NO, probably produced by neuronal NOS, plays a role in 2-DG-induced hypothermia. (C) 1999 Lippincott Williams & Wilkins.
